T2DM合并NAFLD患者肌电图的临床特点

The clinical characteristics of EMG in T2DM patients with NAFLD

目的探讨2型糖尿病(T2DM)患者中合并非酒精性脂肪肝(NAFLD)肌电图的临床特点。方法选取T2DM患者449例,按是否合并N AFLD分为单纯T2DM组(T2DM组)114例,合并NAFLD组(T2DM-NAFLD组)335例。比较两组患者的各项参数,并行相关性分析结果与T2DM组比较,T2DM-NAFLD组体重、腰围、臀围、腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、血清尿酸(SUA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、空腹C肽(FCP)、餐后2小时C肽(2 hCP)、胰岛素抵抗指数(HOMA-IR)值升高明显(P<0.05)。Pearson相关分析显示,肌电图异常与ALT、FCP、2 hCP、HOMA-IR呈负相关,与年龄、糖化血红蛋白(HbAlc)呈正相关。进一步行Logistic分析,年龄、HbAlc为肌电图异常的独立危险因素,结论合并NAFLD的T2DM患者肌电图异常的患病率较低,机制不明。年龄、HbA1c为肌电图异常的独立危险因素。

Objective To explore the clinical features of electromyography in patients with non—alcoholic fatty liver(NAFLD)newly diagnosed with type 2 diabetes(T2DM).Methods A total of 449 newly diagnosed T2DM patients were selected.They were divided into 114 cases in the simple T2DM group(T2DM group)and 335 cases in the combined NAFLD group(T2DM—NAFLD group)according to whether NAFLD was combined.The parameters of the two groups of patients was compared,and the correlation was analyzed.Results Compared with the T2DM group,the T2DM—NAFLD 0 group's weight,waist circumference,hip circumference,WHR,SBP,DBP,SUA,AST,ALT,TC,TG,LDL,FCP,2 hCP,HOMA-IK values increased(P<0.05).Pearson correlation analysis showed that abnormal EMG was negatively correlated with ALT,FCP,2 hCP,HOMA—IR,and positively correlated with age and HbAlc.Further Logistics analysis showed that age and HbAlc were independent risk factors for abnormal EMG.Conclusion The prevalence of abnormal EMG in newly diagnosed T2DM patients with NAFLD is low,and the mechanism is unknown.Age and HbAlc are independent risk factors for abnormal EMG.