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正常白蛋白尿糖尿病肾病相关临床资料分析 被引量:2

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摘要 目的通过分析正常白蛋白尿糖尿病肾病(NADKD)患者的一般临床资料,探讨NADKD发生的相关危险因素。方法收集2019年1月至2020年1月上海健康医学院附属周浦医院内分泌科住院的2型糖尿病患者586例一般临床资料,按照肾小球滤过率(eGFR)或随机尿微量白蛋白(U-mALB)情况分成三组,单纯糖尿病组338例、微量白蛋白尿糖尿病肾病组195例、NADKD组35例;记录并比较各组之间的临床资料,分析NADKD发生的相关危险因素。结果所有收集的糖尿病患者中NADKD占比为6%,微量白蛋白尿糖尿病肾病占比为33.3%;NADKD组女性患者、合并高血压者比例增高(P<0.05);NADKD组尿胱抑素C(CysC)水平高于单纯糖尿病组及微量白蛋白尿糖尿病肾病组(P<0.05);多因素Logistic回归分析,性別、合并高血压、尿胱抑素C是发生NADKD的独立危险因素(P<0.05)。结论在2型糖尿病患者中,NADKD的发生率明显低于微量白蛋白尿糖尿病肾病患者,与微量白蛋白尿糖尿病肾病患者相比,女性且合并高血压的糖尿病患者更容易发生NADKD,尿CysC作为NADKD发生的预测指标有待进一步研究证实。 Objective To analyze the general clinical data of patients with normal albuminuria diabetic nephropathy(NADKD)and explore the nsk tactors of NADKD.Methods From January 2019 to January 2020,586 patients with type 2 diabetes in the Department of Endocnnology,Zhouou Hospital Affiliated to Shanghai Health Medical College were divided into three groups according to the glomerular filtrarion rate(eGFR)or random urinary microalbumin,338 patients in the simple diabetes group and 195 patients in the microalbuminuria diabetic nephropathy group,35 cases of NADKD group.The clinical data between each group were recorded and compared,the risk factors related to the occurrence of NADKD were analyzed.Results The percentage of NADKD was 6% and that of microalbuminuria diabetic nephropathy was 33.3%.The percentage of women in NADKD group and those with hypertension was higher than that in simple diabetes group and microalbuminuria diabetic nephropathy group(P<0.05).The level of urinary cystatin C(CysC)in NADKD group was higher than that in simple diabetes group and microalbuminuria diabetic nephropathy group(P<0.05).Multivariate Logistic regression analysis showed that sex,hypertension and urinary CysC were independent risk factors for NADKD(P<0.05).Conclusion In type 2 diabetic patients,the incidence of NADKD is significantly lower than that of microalbuminuria diabetic nephropathy.Compared with microalbuminuna diabetic nephropathy,women with hypertension are more likely to develop NADKD.Urinary CysC as a predictor of the occurrence of NADKD needs further study and confirmation.
出处 《浙江临床医学》 2021年第2期202-203,共2页 Zhejiang Clinical Medical Journal
基金 上海市浦东新区卫生和计划生育委员会学科建设特色专病-糖尿病(PWZzb2017-25)。
关键词 正常白蛋白尿糖尿病肾病 微量白蛋白尿糖尿病肾病 胱抑素C Normal albuminuria diabetic nephropathy Microalbuminuria diabetic nephropathy Cystatin C
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