33例新型冠状病毒肺炎患者治疗后的咽拭子和痰标本核酸检测结果比较

Comparison of viral nucleic acid test results of pharyngeal swabs versus induced sputum specimens in 33 patients with COVID-19 after treatment

目的:通过比较新型冠状病毒肺炎患者治疗后的咽拭子和痰标本核酸检测结果,探讨痰标本核酸结果作为筛查新型冠状病毒肺炎患者及判断疗效依据的可能性。方法:收集33例患者的咽拭子和痰标本病毒核酸检测结果。结果:痰标本核酸阳性率明显高于咽拭子,33.3%患者咽拭子新型冠状病毒核酸阴性而痰标本核酸阳性。结论:以咽拭子标本病毒核酸阴性作为排除诊断及出院标准须重新评估其可靠性,建议检测痰标本病毒核酸作为新型冠状病毒肺炎患者排除诊断和解除隔离的依据之一。

Objective: To investigate the possibility of screening COVID-19 patients with sputum viral nucleic acid results by comparing the nucleic acid test results between pharyngeal swab and induced sputum after treatment.Methods: The viral nucleic acid results of 33 COVID-19 patients though pharyngeal swab and sputum specimen were collected and compared.Results: The nucleic acid postive rate of sputum was significantly higher than that of pharyngeal swab, 33. 3% patients whose results were negative in pharyngeal swabs for viral nucleic acid detection, were tested positive in sputum specimens.Conclusion: Although the results of pharyngeal swabs nucleic acid test are adopted as the current diagnosis and discharge standards for COVID-19, viral nucleic acid detection of induced sputum specimens is also recommended as a reference for final diagnosis and disisolation.