血管内皮生长因子表达水平与宫颈癌患者预后的关系

Relationship between expression level of vascular endothelial growth factor and prognosis of cervical cancer patients

目的探讨血管内皮生长因子(VEGF)表达水平与宫颈癌患者预后的关系。方法以136例宫颈癌患者为研究对象,分别采用免疫组化法和酶联免疫法对其癌组织和血清中VEGF的表达水平进行半定量和定量检测。分析VEGF表达水平与宫颈癌临床病理特征及预后的相关性,并通过Cox风险回归模型明确VEGF表达水平与宫颈癌患者预后的独立相关性。结果宫颈癌患者癌组织和血清中VEGF的表达水平均与肿瘤直径、FIGO分期、分化程度和淋巴结转移有关,且与宫颈癌患者的预后有关。多因素分析显示,调整FIGO分期、分化程度、淋巴结转移和肿瘤直径后,宫颈癌组织中VEGF的高表达水平与宫颈癌患者预后不良独立相关(HR:2.217,95%CI:1.574~3.158),宫颈癌患者血清VEGF水平升高亦与宫颈癌患者预后不良独立相关(HR:1.192,95%CI:1.083~1.223)。结论宫颈癌患者癌组织和血清中VEGF的表达水平与肿瘤直径、FIGO分期、淋巴结转移和分化程度有关,且是宫颈癌预后不良的独立危险因素,能够应用于宫颈癌患者预后的预测。

Objective To explore the relationship between expression level of vascular endothelial growth factor(VEGF)and prognosis of cervical cancer patients.Methods A total of 136 cervical cancer patients were collected as study object.The expression levels of VEGF in cervical cancer tissue and serum were detected by immunohistochemical method and ELISA,respectively.The relationships between expression level of VEGF and clinicopathological characteristics and prognosis of cervical cancer patients were analyzed,COX proportional hazard regression model was used to analyze the independent correlation between VEGF expression level and prognosis of cervical cancer patients.Results The expression levels of VEGF in cervical cancer tissue and serum were correlated with tumor diameter,FIGO stage,differentiation degree,lymph node metastasis,and prognosis of cervical cancer patients.Multivariate analysis showed that high expression level of VEGF in cervical cancer tissue was independently correlated with poor prognosis of cervical cancer patients after adjusting FIGO stage,differentiation degree,lymph node metastasis,and tumor diameter(HR:2.217,95%CI:1.574-3.158),high expression level of VEGF in serum of cervical cancer patients was independently correlated with poor prognosis of cervical cancer patients(HR:1.192,95%CI:1.083-1.223).Conclusion The expression levels of VEGF in cervical cancer tissue and serum are correlated with tumor diameter,FIGO stage,lymph node metastasis,and differentiation degree of cervical cancer patients,which is the independently risk factor of poor prognosis of cervical cancer patients,VEGF can be used in predicting prognosis of cervical cancer patients.