丙种球蛋白辅助治疗对重症肺炎合并心力衰竭患儿预后的改善效果

Improvement effect of assisted therapy of immunoglobulin on prognosis of children with severe pneumonia complicated with heart failure

目的分析丙种球蛋白辅助治疗对重症肺炎合并心力衰竭患儿预后的改善效果。方法选取2017年5月-2018年10月湖州市南浔区人民医院收治的重症肺炎合并心力衰竭患儿80例,采用随机数字表分为观察组和对照组,每组40例患儿。两组患儿均进行常规治疗,观察组在对照组基础上给予丙种球蛋白治疗。比较两组患儿的疗效,IgG水平,T细胞亚群CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)水平,阳性症状、体征的缓解时间及住院时间。结果观察组患儿有效率为95.00%,显著高于对照组患儿的72.50%(P<0.05)。治疗后,观察组患儿IgG、CD4^(+)、CD4^(+)/CD8^(+)水平显著高于对照组患儿(均P<0.05),CD8^(+)水平显著低于对照组患儿(P<0.05)。治疗后,观察组患儿IgG、CD4^(+)、CD4^(+)/CD8^(+)水平显著高于治疗前(均P<0.05),CD8^(+)水平显著低于治疗前(P<0.05)。观察组患儿阳性症状、体征的缓解时间及住院时间均显著短于对照组患儿(均P<0.05)。结论丙种球蛋白辅助治疗可提高重症肺炎合并心力衰竭患儿的疗效,增强患儿免疫功能,减轻阳性症状与体征,缩短住院时间,改善预后,值得临床推广。

Objective To analyze the improvement effect of assisted therapy of immunoglobulin on prognosis of children with severe pneumonia complicated with heart failure.Methods From May 2017 to October 2018,80 children with severe pneumonia complicated with heart failure treated in People's Hospital of Nanxun District were selected and divided into observation group and control group,40 children in each group.The children in the two groups were treated routinely,the children in observation group were treated by immunoglobulin based on control group.The curative effects,IgG levels,CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)levels,the remission time of positive symptoms and signs,hospitalization time in the two groups were compared.Results The effective rate in observation group was 95.00%,which was statistically significantly higher than that in control group(72.50%)(P<0.05).After treatment,the levels of IgG,CD4^(+),CD4^(+)/CD8^(+)in observation group were statistically significantly higher than those in control group(P<0.05),while CD8^(+)level was statistically significantly lower than that in control group(P<0.05).After treatment,the levels of IgG,CD4^(+),CD4^(+)/CD8^(+)in observation group were statistically significantly higher than those before treatment(P<0.05),while CD8^(+)level was statistically significantly lower than that before treatment(P<0.05).The remission time of positive symptoms and signs,hospitalization time in observation group was statistically significantly shorter than that in control group(P<0.05).Conclusion Assisted therapy of immunoglobulin can improve curative effect of children with severe pneumonia complicated with heart failure,enhance immune function,relieve positive symptoms and signs,shorten hospitalization time,and improve prognosis,which is worthy of clinical promotion.