百令胶囊联合吗替麦考酚酯对过敏性紫癜性肾炎患儿肾功能、体液免疫功能及血清炎性因子的影响

Effect of Bailing Capsule Combined with Mycophenolate Mofetil on Renal Function,Humoral Immune Function and Serum Inflammatory Factors in Children with Henoch Schonlein Purpura Nephritis

目的:探讨百令胶囊联合吗替麦考酚酯对过敏性紫癜性肾炎(HSPN)患儿肾功能、体液免疫功能及血清炎性因子的影响。方法:选取2014年7月~2020年2月期间我院收治的80例HSPN患儿,按照随机数字表法分为对照组(n=40,吗替麦考酚酯治疗)和观察组(n=40,百令胶囊联合吗替麦考酚酯治疗),对比两组疗效、肾功能[24 h尿蛋白定量(24 h Upro)、血肌酐(Scr)、尿素氮(BUN)]、体液免疫功能[免疫球蛋白(Ig)M、IgA、IgG]及血清炎性因子[γ-干扰素(IFN-γ)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)],记录两组治疗期间不良反应情况。结果:与对照组相比,观察组的总有效率更高(P<0.05)。两组不良反应发生率对比未见差异(P>0.05)。治疗3个月后,两组Scr、24 h Upro、BUN、IgM、IgA、IgG、IFN-γ、IL-6、TNF-α均较治疗前下降,且观察组较对照组低(P<0.05)。结论:百令胶囊联合吗替麦考酚酯治疗HSPN患儿疗效值得肯定,可有效改善患儿肾功能、体液免疫功能,减轻患儿炎性反应,且安全性较好。

Objective:To investigate the effect of Bailing capsule combined with mycophenolate mofetil on renal function,humoral immune function and serum inflammatory factors in children with Henoch Schonlein purpura nephritis(HSPN).Methods:80 cases of children with HSPN in our hospital from July 2014 to February 2020 were selected,and divided into control group(n=40,treated with mycophenolate mofetil)and observation group(n=40,treated with Bailing capsule combined with mycophenolate mofetil)according to random number table method.The efficacy,renal function[24 h urinary protein quantification(24 h Upro),blood creatinine(Scr),urea nitrogen(BUN)],humoral immune function[immunoglobulin(Ig)M,IgA,IgG]and serum inflammatory factors[interferon-γ(IFN-γ),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Adverse reactions during treatment in both groups were recorded.Results:Compared with the control group,the total effective rate of the observation group was higher(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).3 months after treatment,Scr,Upro,BUN,IgM,IgA,IgG,IFN-γ,IL-6,TNF-αin the two groups decreased compared with those before treatment,and the observation group was lower than the control group(P<0.05).Conclusion:Bailing capsule combined with mycophenolate mofetil in the treatment of children with HSPN has a positive effect,which can effectively improve the renal function and humoral immune function,reduce the inflammatory reaction of children,and it has a good safety.