中老年健康体检人群多项肿瘤标志物筛查结果及与年龄和性别的关系分析

Analysis the Results of Multiple Tumor Markers Screening and Their Relationship with Age and Gender in Middle-aged and Elderly People

目的:研究中老年健康体检人群多项肿瘤标志物(TM)筛查结果,分析其与年龄和性别的关系。方法:将自2017年6月至2019年12月于我院接受健康体检的600例中老年体检者纳入研究,分别以流式荧光发光法检测甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原-153(CA-153)、糖类抗原-125(CA-125)水平,并分析不同性别、年龄的体检者上述TM阳性率情况,分析各项TM阳性率检出疾病情况。结果:600例体检者AFP、CEA、CA-153、CA-125水平分别为(17.48±3.84)ng/mL、(4.54±1.19)ng/mL、(29.23±7.10)U/m L、(30.65±6.39)U/m L,阳性率分别为1.67%、4.00%、3.33%、3.83%。男性体检者CEA及CA-153阳性率均高于女性,而CA-125阳性率低于女性(P<0.05);男性与女性AFP阳性率对比不明显(P>0.05)。81~89岁体检者的AFP、CEA、CA-153、CA-125阳性率均高于其他年龄段体检者(P<0.05)。AFP、CEA、CA-153、CA-125阳性体检者恶性肿瘤检出率较低。结论:AFP、CEA、CA-153、CA-125表达升高,可能是中老年人群肿瘤发生、发展的早期预警,应予以高度重视,且和年龄、性别关系密切。中老年人群定期体检能够早期发现疾病并治疗,防止疾病继续恶化,保证身心健康。

Objective: To study the results of multiple tumor markers(TM) screening and to analyze their relationship with age and gender in middle-aged and elderly people. Methods: From June 2017 to December 2019, middle-aged and elderly people who underwent physical examination in our hospital were included in the study. The expression levels of alpha-fetoprotein(AFP), carcinoembryonic antigen(CEA), carbohydrate antigen-153(CA-153), carbohydrate antigen-125(CA-125) were detected by flow fluorescent luminescence method, and the above positive rates of TM of physical examinees of different genders and ages were analyzed. The positive rate of TM disease detection was analyzed. Results: In the 600 physical examinees, the levels of AFP, CEA, CA-153 and CA-125 were(17.48±3.84) ng/m L,(4.54±1.19) ng/mL,(29.23±7.10) U/m L and(30.65±6.39) U/mL, respectively, with positive rates of 1.67%, 4.00%,3.33% and 3.83%. The positive rates of CEA and CA-153 in male physical examinees were higher than those in female, while the positive rates of CA-125 were lower than that in female(P<0.05). There was no significant difference in positive rate of AFP between male and female(P>0.05). The positive rates of AFP, CEA, CA-153 and CA-125 in 81 ~ 89 years physical examinees were all higher than those in other age physical examinees(P<0.05). The detection rate of malignant tumor in AFP, CEA, CA-153 and CA-125 positive physical examination were lower. Conclusion: The elevated expressions of AFP, CEA, CA-153 and CA-125 may be an early warning of the occurrence and development of tumors in middle-aged and elderly physical examination population, which should be attached great importance and closely related to age and gender. Regular physical examination of middle-aged and elderly people can early detection of diseases and treatment, prevent the disease from worsening, to ensure physical and mental health.