血清SAA、BDNF、ALP水平与脑梗死后认知功能障碍的相关性

Correlation Between Serum SAA,BDNF,ALP Levels and Cognitive Dysfunction after Cerebral Infarction

目的探讨血清碱性磷酸酶(ALP)、血清淀粉样蛋白A(SAA)、脑源性神经营养因子(BDNF)与脑梗死后认知功能障碍(PSCI)的相关性。方法纳入2018年2月~2020年2月我院125例脑梗死患者,评价美国国家卫生研究所卒中量表(NIHSS),根据是否发生PSCI设为PSCI组(45例)与非PSCI组(80例),选择同期入院体检的50例正常人群设为对照组,检测各组血清SAA、BDNF、ALP水平并分析与认知功能障碍的相关性。结果 PSCI组、非PSCI组患者血清ALP、SAA水平显著高于对照组,BDNF水平、MMSE评分显著低于对照组,且PSCI组与非PSCI组血清指标、MMSE评分、NIHSS评分差异具有统计学意义(P<0.05);PSCI组中轻、中、重度PSCI患者血清ALP、SAA、BDNF水平、NIHSS评分、MMSE评分差异具有统计学意义(P<0.05);血清ALP、SAA水平与MMSE评分呈显著负相关,与NIHSS评分呈正相关,血清BDNF水平与MMSE评分呈显著正相关,与NIHSS评分呈负相关(P<0.05)。结论脑梗死后PSCI发生率较高,且血清SAA、BDNF、ALP与PSCI密切相关,可用于脑梗死后PSCI的早期诊断与预测。

Objective To explore the correlation between serum alkaline phosphatase(ALP),serum amyloid A(SAA),brain-derived neurotrophic factor(BDNF)and cognitive dysfunction(PSCI)after cerebral infarction. Methods A total of 125 patients with cerebral infarction in our hospital from February 2018 to February 2020 were included and evaluated by national institutes of health stroke scale(NIHSS). They were set as the PSCI group(45 cases)and the non-PSCI group(80 cases)from February 2018 to February 2020 were included and evaluated by national institutes of health stroke scale(NIHSS). They were set as the PSCI group(45 cases)and the non-PSCI group(80 cases)according to whether PSCI occurs.50 normal people who were admitted to the hospital for physical examination during the same period were selected as the control group,and the serum SAA,BDNF,and ALP levels of each group were detected and the correlation with cognitive dysfunction was analyzed. Results The serum ALP and SAA levels of the PSCI group and the non-PSCI group were significantly higher than those of the control group,and the BDNF level and MMSE score were significantly lower than those of the control group. The differences in serum indexes,MMSE score,and NIHSS score between the PSCI group and the non-PSCI group were statistically significant(P<0.05). There were statistically significant differences in serum ALP,SAA,BDNF levels,NIHSS scores,and MMSE scores in patients with mild,moderate,and severe PSCI in the PSCI group(P<0.05). Serum ALP and SAA levels were significantly negatively correlated with MMSE score,positively correlated with NIHSS score,serum BDNF level was significantly positively correlated with MMSE score,and negatively correlated with NIHSS score(P<0.05). Conclusion The incidence of PSCI is relatively high after cerebral infarction,and serum SAA,BDNF,ALP are closely related to PSCI,which can be used for the early diagnosis and prediction of PSCI after cerebral infarction.