血清不饱和脂肪酸、维生素D及雌激素水平与产后抑郁的关系

Relationship between serum unsaturated fatty acids,vitamin D and estrogen levels and postpartum depression

目的探讨血清不饱和脂肪酸、维生素D及雌激素水平与产后抑郁的关系。方法选择我院2016年2月~2018年2月200例产后抑郁患者以及200名非抑郁产妇为研究对象,分别设为抑郁组与非抑郁组,比较两组血清不饱和脂肪酸、维生素D及雌激素水平,并分析其与抑郁情绪的相关性。结果抑郁组产后抑郁量表(EP-DS)评分显著高于对照组,血清20碳五烯酸(EPA)、生四烯酸(AA)、22碳六烯酸(DHA)水平均显著低于非抑郁组,(P<0.05);抑郁组血清孕酮(P)、雌二醇(E2)、维生素D水平均显著低于非抑郁组,(P<0.05);血清EPA、AA、 DHA水平、P、E2、维生素D水平与EP-DS评分呈显著负相关(P<0.05)。结论产后抑郁的发生与发展可能与血清不饱和脂肪酸、维生素D及雌激素水平有关。

Objective To explore the relationship between serum unsaturated fatty acids,vitamin D,estrogen levels and postpartum depression. Methods A total of 200 patients with postpartum depression and 200 nondepressive puerpera from February 2016 to February 2018 in our hospital were selected and divided into the depressive group and the non-depressive group. The levels of serum unsaturated fatty acids,vitamin D and estrogen in the two groups were compared,and their correlation with depression were analyzed. Results The depression group edinburgh postpartum depression scale(EP-DS)score was significantly higher than the control group. Serum levels of 20-carbon pentaenoic acid(EPA),tetratetraenoic acid(AA),and 22-carbon hexaenoic acid(DHA)were significantly lower than those in the non-depressive group(P<0.05). The levels of serum progesterone(P),estradiol(E2),and vitamin D in the depression group were significantly lower than those in the non-depression group(P<0.05). Serum EPA,AA,DHA levels,P,E2,and vitamin D levels were significantly negatively correlated with EP-DS scores(P<0.05). Conclusion The occurrence and development of postpartum depression may be related to abnormal of serum unsaturated fatty acids,vitamin D and estrogen levels.