CRRT对重症急性胰腺炎患者炎症因子及肠黏膜屏障功能的影响

Effect of CRRT on inflammatory factors and intestinal mucosal barrier function in patients with severe acute pancreatitis

目的:探讨连续性肾脏替代(CRRT)对重症急性胰腺炎患者炎症因子及肠黏膜屏障功能的影响。方法:选取重症急性胰腺炎患者73例,采用随机数字表法分为对照组(37例)和观察组(36例)。对照组采用肠外营养支持、解痉止痛、抗感染等对症治疗,观察组则联合CRRT治疗,对比两组炎性因子水平和血浆D-乳酸、二胺氧化酶(DAO)水平。结果:治疗7 d后,观察组炎性因子水平、血浆D-乳酸、DAO水平均明显低于对照组,差异有统计学意义(P<0.05)。结论:CRRT能降低重症急性胰腺炎患者血液炎症因子水平,改善肠黏膜屏障功能。

Objective: To investigate the effects of continuous renal replacement therapy(CRRT)on inflammatory factors and intestinal mucosal barrier function in patients with severe acute pancreatitis(SAP). Methods: 73 patients with severe acute pancreatitis were randomized into the control group(37 cases)and observation group(36 cases). The control group were treated with parenteral nutrition such as spasmolysis, pain relief and anti-infection, while the observation group received CRRT treatment. The levels of inflammatory factors, plasma D-lactate and diamine oxidase(DAO)were compared between the two groups. Results: After 7 days of treatment, the levels of inflammatory factors, plasma D-lactic acid and DAO in the observation group were significantly lower than those in the control group, which were of statistical differences(P<0.05). Conclusion: CRRT can reduce the level of blood inflammatory factors and improve the intestinal mucosal barrier function in patients with severe acute pancreatitis.