CO呼气试验方式检测4种常见恶性血液病红细胞寿命长短分析及检测意义

Analysis and significance of detection of RBC life span in four common malignant hematological diseases by CO breath test

目的应用CO呼气试验方式检测4种常见恶性血液病[急性髓系白血病(AML)、骨髓增生异常综合征(MDS)、多发性骨髓瘤(MM)及原发性骨髓纤维化(PMF)]患者红细胞寿命长短,并探讨其检测意义。方法收集2019年2-11月于河北省中医院血液病科住院及门诊的AML、MDS、MM及PMF患者80例作为研究对象,分为AML组、MDS组、MM组、PMF组,每组各20例患者,另选取同期该院体检健康者50例作为对照组。应用CO呼气试验方式测定各组红细胞寿命长短。结果AML组、MDS组、MM组、PMF组红细胞寿命,与对照组比较,差异有统计学意义(P<0.05)。4组恶性血液病患者红细胞寿命之间两两比较,差异有统计学意义(P<0.05)。结论CO呼气试验方式可准确检测红细胞寿命,可用于完善恶性血液病贫血机制研究,值得临床推广应用。

Objective To determine the erythrocyte life span in patients with four common hematologic malignancies[acute myeloid leukemia(AML),myelodysplastic syndrome(MDS),multiple myeloma(MM)and primary myelofibrosis(PMF)]by CO breath test,and to explore its significance.Methods A total of 80 patients with AML,MDS,MM and PMF who were admitted to the inpatient and outpatient departments of hematology department of Hebei hospital of traditional Chinese medicine from February to November 2019 were selected as the study subjects.They were divided into AML group,MDS group,MM group and PMF group with 20 patients in each group.Fifty healthy subjects who were examined in a hospital during the same period were selected as the control group.CO breath test was used to determine the life span of red blood cells in each group.Results Compared with the control group,the erythrocyte life span of AML group,MDS group,MM group and PMF group had statistical significance(P<0.05).There was statistically significant difference in the erythrocyte life span among the 4 groups(P<0.05).Conclusion The CO breath test can accurately detect the life of red blood cells,and can be used to improve the mechanism of anemia in hematologic malignancies.It is worthy of clinical application.