葡萄糖酸锌颗粒联合消旋卡多曲颗粒对轮状病毒性肠炎患儿血浆炎性因子、心肌酶指标及免疫功能的影响

Effects of Zinc Gluconate Combined with Racecadotril on Plasma Inflammatory Factors, Myocardial Enzymes and Immune Function in Children with Rotavirus Enteritis

目的:探讨葡萄糖酸锌颗粒联合消旋卡多曲颗粒对轮状病毒性肠炎患儿血浆炎性因子、心肌酶指标及免疫功能的影响。方法:选取2017年2月~2019年7月期间于我院门诊就诊的轮状病毒性肠炎患儿97例,根据随机数字表法分为对照组(n=48)和研究组(n=49),在常规治疗的基础上对照组患儿给予消旋卡多曲颗粒治疗,研究组在对照组的基础上联合葡萄糖酸锌颗粒治疗,比较两组患儿疗效、血浆炎性因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、血清心肌酶指标[乳酸脱氢酶(LDH)、磷酸肌酸激酶同工酶(CK-MB)和磷酸肌酸激酶(CK)]及免疫功能指标(CD4+、CD8+、CD4+/CD8+)的变化情况,记录两组治疗期间不良反应发生情况。结果:研究组治疗7 d后的临床总有效率为91.84%(45/49),高于对照组的75.00%(36/48)(P<0.05)。两组治疗7 d后血浆IL-6、TNF-α水平均下降,且研究组低于对照组(P<0.05)。两组治疗7d后血清LDH、CK、CK-MB水平均下降,且研究组低于对照组(P<0.05)。两组治疗7 d后CD8+下降,且研究组低于对照组(P<0.05);CD4+、CD4+/CD8+升高,且研究组高于对照组(P<0.05)。两组不良反应发生率对比未见统计学差异(P>0.05)。结论:葡萄糖酸锌颗粒联合消旋卡多曲颗粒治疗轮状病毒性肠炎患儿疗效显著,可改善患儿炎性因子、心肌酶指标,提升患儿免疫功能,且未见严重不良反应发生。

Objective: To investigate the effect of zinc gluconate combined with racecadotril on plasma inflammatory factors,myocardial enzymes and immune function in children with rotavirus enteritis. Methods: A total of 97 children with rotavirus enteritis who were admitted to our hospital from February 2017 to July 2019 were selected, they were randomly divided into control group(n=48) and study group(n=49) according to the random number table method. On the basis of routine treatment, the control group was treated with racecadotril granules. The study group was treated with zinc gluconate oral solution on the basis of the control group. The efficacy and plasma inflammatory factors [interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), serum myocardial enzyme indexes lactate dehydrogenase(LDH), creatine phosphokinase-isoenzyme-MB(CK-MB) and creatine phosphokinase(CK)] and immune function indexes(CD4^+, CD8^+, CD4^+/CD8^+) changes of two groups were compared. Results: The total clinical effective rate of the study group at 7 d after treatment was 91.84%(45/49), which was higher than 75.00%(36/48) of the control group(P<0.05). The levels of plasma IL-6 and TNF-α of the two groups decreased at 7 days after treatment, and the levels of the study group were lower than those of the control group(P<0.05). The levels of LDH, CK and CK-MB of the two groups decreased at 7 days after treatment, and the levels of the study group were lower than those of the control group(P<0.05). 7 days after treatment, CD8+of the two groups decreased at 7 days after treatment,and that of the study group was lower than that of the control group(P<0.05). CD4^+, CD4^+/CD8^+were increased, and that of the study group were higher than that of the control group(P<0.05). No serious adverse reactions were found in the two groups(P>0.05).Conclusion: Zinc gluconate combined with racecadotril in the treatment of rotavirus enteritis children has a significant effect, which can improve the inflammatory factors and myocardial enzyme indexes, and enhance the immune function of children, and no serious adverse reactions have been observed.