慢性乙型肝炎患者血清IL-17A、GP73水平与肝功能指标及病情严重程度的关系分析

Correlation Analysis of Serum IL-17A and GP73 Levels with Liver Function Indexes and Disease Severity in Patients with Chronic Hepatitis B

目的:探讨慢性乙型肝炎(CHB)患者血清白细胞介素-17A(IL-17A)、高尔基体蛋白73(GP73)水平与肝功能指标及病情严重程度的关系。方法:选取2018年10月至2019年10月于青海大学附属医院就诊的CHB患者93例作为研究对象(CHB组),另选取同时期于我院体检的健康志愿者33例作为对照组。比较不同病情严重程度、不同乙型肝炎e抗原(HbeAg)表达的CHB患者IL-17A、GP73水平及肝功能相关指标[丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、白蛋白、总胆红素(TBi L)]的差异,并分析IL-17A、GP73水平与患者病情严重程度及肝功能相关指标的相关性。结果:CHB组中轻度、中度、重度患者血清IL-17A、GP73、ALT、AST及TBi L水平均高于对照组,白蛋白水平低于对照组(P<0.05),并且随着CHB患者病情严重程度的加重其血清中IL-17A、GP73、ALT、AST及TBi L水平逐渐升高,白蛋白水平逐渐降低(P<0.05)。CHB组HbeAg阴性患者血清中的IL-17A、GP73、ALT及AST水平均明显高于HbeAg阳性患者(P<0.05),而白蛋白和TBi L水平无明显差异(P>0.05)。CHB患者血清IL-17A、GP73均与ALT、AST及TBi L呈正相关,与白蛋白呈负相关,与患者病情严重程度呈正相关(P<0.05)。结论:CHB患者血清中IL-17A、GP73水平明显升高,且与患者病情严重程度及肝功能相关指标呈明显相关性,临床中可联合检测用于患者病情评估及预后监测。

Objective: To investigate the relationship between the serum interleukin-17 a(IL-17 A) and golgi protein 73(GP73)levels with liver function indexes and disease severity in patients with chronic hepatitis B(CHB). Methods: A total of 93 patients with CHB who were treated in Qinghai University Affiliated Hospital from October 2018 to October 2019 were selected as the study objects(CHB group), and 33 healthy people who were examined in the same period in Qinghai University Affiliated Hospital were selected as the control group. The IL-17 A, GP73 levels and the related indexes of liver function aminotransferase(ALT), aspartate aminotransferase(AST), albumin, total bilirubin(TBi L) were compared in patients with different degree of disease and different indexes expression of hepatitis be antigen(HbeAg). The correlation between the IL-17 A and GP73 levels and the disease severity and the related indexes of liver function were analyzed. Results: The serum IL-17 A, GP73, ALT, AST and TBi L levels in patients with mild, moderate and severe CHB were higher than those in the control group, the albumin level was lower than the control group(P<0.05). With the aggravation of CHB, the serum IL-17 A, GP73, ALT, AST and TBi L levels gradually increased and the albumin level gradually decreased(P<0.05). The serum IL-17 A, GP73, ALT and AST levels in HBeAg negative patients were significantly higher than those in HBeAg positive patients in CHB group(P<0.05) and there was no significant difference in albumin and TBi L levels(P<0.05). The serum IL-17 A and GP73 levels were positively correlated with ALT, AST and TBi L, negatively correlated with albumin and positively correlated with the disease severity of patients with CHB(P<0.05). Conclusion: The serum IL-17 A and GP73 levels in patients with CHB are significantly increased and they are significantly correlated with the degree of disease and related liver function index. In clinical, which combined detection can be used for patients’ condition evaluation and prognosis monitoring.