双联抗血小板应用于穿支动脉脑梗塞静脉溶栓后的效果分析

Analysis of the Effect of Dual Antiplatelet after Intravenous Thrombolysis in Patients with Perforator Cerebral Infarction

目的:研究双联抗血小板应用于穿支动脉脑梗塞静脉溶栓后的效果。方法:选取2017年11月~2019年6月某院接收并治疗的50例穿支动脉脑梗塞患者,使用随机数字表法将其分为对照组和双联组各25例。静脉溶栓后对照组单一使用阿司匹林进行治疗,双联组在对照组的基础上使用硫酸氢氯吡格雷进行治疗。治疗两个月后,比较患者的临床疗效、血流情况、不良反应情况。结果:双联组的总有效率(96.00%)高于对照组(76.00%)(P<0.05);治疗后双联组的血浆黏度和血小板聚集均低于对照组(P<0.05);双联组的总不良反应发生率(4.00%)低于对照组(28.00%)(P<0.05)。结论:双联抗血小板应用于穿支动脉脑梗塞静脉溶栓后的效果显著且不良反应较少,对血流的改善更佳。

Objective:To study the effect of dual antiplatelet therapy after intravenous thrombolysis in patients with perforator cerebral infarction.Methods:From November 2017 to June 2019,50 patients with perforator cerebral infarction treated in a hospital were divided into control group and dual group,with 25 cases in each group.After intravenous thrombolysis,the control group was treated with aspirin alone,while the dual group was treated with clopidogrel bisulfate on the basis of the control group.After two months of treatment,the clinical efficacy,blood flow and adverse reactions were compared.Results:The total effective rate of the dual group(96.00%)was higher than that of the control group(76.00%)(P<0.05).After treatment,the plasma viscosity and platelet aggregation of the dual group were lower than those of the control group(P<0.05),and the total incidence of adverse reactions of the dual group(4.00%)was lower than that of the control group(28.00%)(P<0.05).Conclusion:Dual antiplatelet has a significant effect on the improvement of blood flow after intravenous thrombolysis in patients with perforator cerebral infarction,with less adverse reactions.