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结缔组织生长因子/聚L-乳酸纳米微球的制备及其体外释药特性研究 被引量:1

Preparation and in vitro release behavior of connective tissue growth factor-loaded poly(L-lactic acid) nanoparticles
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摘要 目的以聚L-乳酸为载体材料制备结缔组织生长因子纳米微球。方法采用复乳法制备结缔组织生长因子/聚L-乳酸纳米微球,检测微球特征,并观察微球表面形貌,最后研究微球体外释药特性。结果结缔组织生长因子/聚L-乳酸纳米微球平均粒径为(376.5±18.2)nm,包封率为(68.62±1.34)%,载药量为(34.26±0.73)μg/mg。微球呈现良好的球面形貌,表面圆整无明显裂纹和孔隙。该微球释药特性表现为前12 h的药物快速释放和随后30 d的药物缓慢释放。结论该研究制备出来的结缔组织生长因子/聚L-乳酸纳米微球是应用于牙科种植体基台表面的理想微球,具有良好的应用前景。 Objective To prepare nanoparticles containing connective tissue growth factor with poly(L-lactic acid)(PLLA). Methods The connective tissue growth factor-loaded PLLA nanoparticles were prepared by double emulsion method. The characteristics of the nanoparticles were determined, and the morphology of the nanoparticles was observed. Finally, the release behavior of the nanoparticles was examined in vitro. Results The average diameter of the prepared connective tissue growth factor-loaded PLLA nanoparticles was(376.5±18.2) nm, the incorporation efficiency and drug loading were(68.62±1.34) % and(34.26±0.73) μg/mg, respectively. The nanoparticles showed good spherical morphology without aggregation or adhesion. The release profile consisted of an initial fast release in the first 12 h and a more continuous slow release for 30 d. Conclusion The connective tissue growth factor-loaded PLLA nanoparticles prepared in this study are ideal nanoparticles to be applied on dental implant abutment surface.
作者 程义成 孔祥伟 梅盛林 尹伟 王晨辰 刘向辉 Cheng Yicheng;Kong Xiangwei;Mei Shenglin(Dept of Stomatology,General Hospital of Eastern Theater,Nanjing 210002;Dept of Prothodontics,College of Stomatology,Xi’an Jiaotong University,Xi'an 710004)
出处 《安徽医科大学学报》 CAS 北大核心 2021年第1期18-21,共4页 Acta Universitatis Medicinalis Anhui
基金 国家自然科学基金(编号:81901046) 江苏省自然科学基金资助项目(编号:BK20170115) 中央高校基本科研业务费专项资金项目(编号:xzy012019097)。
关键词 结缔组织生长因子 纳米微球 体外释药 种植体基台 connective tissue growth factor nanoparticles release behavior in vitro implant abutment
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