慢性酒精中毒性精神障碍患者认知功能研究

Study on cognitive function of patients with chronic alcoholic mental disorder

目的:探讨慢性酒精中毒性精神障碍患者的认知功能变化。方法:选取慢性酒精中毒性精神障碍患者60例,作为研究组;选取健康志愿者60例,作为对照组。两组均应用事件相关电位(ERPs)内源性成分P300和蒙特利尔认知功能评估量表(MoCA)进行认知功能检测。结果:研究组患者随着饮酒时间的延长,MoCA各项目评分随之降低,与对照组比较,差异有统计学意义(P<0.05);研究组MoCA子相中的视空间、注意力及记忆力评分低于对照组,差异有统计学意义(P<0.05);与对照组比较,研究组ERP的P3a、P3b潜伏期延长、波幅降低,差异有统计学意义(P<0.05)。结论:慢性酒精中毒性精神障碍患者早期认知功能受损,且饮酒时间越长、受损越严重。

Objective:To explore the changes of cognitive function of patients with chronic alcoholic mental disorder.Methods:60 patients with chronic alcoholism mental disorder were selected as the study group.60 healthy volunteers were selected as the control group.P300 of the endogenous component of event-related potentials(ERPs)and Montreal Cognitive Assessment Scale(MoCA)were used to test the cognitive function of both groups.Results:With the extension of drinking time,MOCA scores of the study group decreased,compared with the control group,the difference was statistically significant(P<0.05).In the study group,the scores of visual space,attention and memory in MOCA were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Compared with the control group,the latency of P3a and P3b of ERP in the study group was longer and the amplitude was lower,the difference was statistically significant(P<0.05).Conclusion:In patients with chronic alcoholic mental disorder,early cognitive function is impaired,and the longer the drinking time,the more serious the impairment.