阴离子交换蛋白2与原发性胆汁性胆管炎发病机制的关系

Role of anion exchanger 2 in the pathogenesis of primary biliary cholangitis

原发性胆汁性胆管炎(PBC)的致病原因和发病机制仍不明确。目前主要认为胆管微环境变化和自身免疫反应是其发病的主要因素。阴离子交换蛋白2(AE2)是一种位于上皮细胞细胞膜上的HCO3-/Cl-交换蛋白,因发现其可以诱发和加重PBC的病程而被广大学者重视。从AE2以及相关调控机制着手,归纳总结了AE2在胆管微环境和自身免疫反应中所起到的作用,进一步对PBC的发病机制进行分析,以期通过探索AE2在PBC中的调控机制寻找到潜在的PBC治疗新方法以及诊断和预后判断指标。

The etiology and pathogenesis of primary biliary cholangitis(PBC)remain unclear at present,and it is believed that the change in bile duct microenvironment and autoimmune response are the main factors for the onset of this disease.Anion exchanger 2(AE2)is an HCO3-/Cl-exchange protein located on the membrane of epithelial cells and has been taken seriously by scholars since studies have shown that it can induce and aggravate PBC.This article summarizes the role of AE2 in bile duct microenvironment and autoimmune response from the aspects of AE2 and related regulatory mechanisms and further analyzes the pathogenesis of PBC,so as to find new therapies and diagnostic and prognostic indicators for PBC by exploring the regulatory mechanism of AE2 in PBC.