复方斑蝥胶囊联合GP化疗治疗晚期非小细胞肺癌的效果

Effect of Compound Cantharidin Capsules combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer

目的探讨复方斑蝥胶囊联合吉西他滨联合顺铂(GP)化疗治疗晚期非小细胞肺癌(NSCLC)的效果。方法选择2017年1月—2019年12月吉林大学第一医院二部收治的82例晚期NSCLC患者,按照随机数字表法分为对照组(n=41)和研究组(n=41)。对照组给予GP化疗方案治疗,研究组在此基础上联合复方斑蝥胶囊治疗。比较两组临床疗效、免疫功能及肿瘤标志物相关指标,记录两组不良反应发生情况。结果研究组治疗后临床总有效率高于对照组(P<0.05)。治疗后,两组CD3+、CD4+、CD4+/CD8+、自然杀伤(NK)细胞水平均低于治疗前,CD8+水平高于治疗前,但研究组CD3+、CD4+、CD4+/CD8+、NK细胞水平均高于对照组,CD8+水平低于对照组(P<0.05)。治疗后,两组癌胚抗原、鳞状细胞癌相关抗原、细胞角蛋白19片段水平均低于治疗前,且研究组低于对照组(P<0.05)。研究组不良反应发生率低于对照组(P<0.05)。结论复方斑蝥胶囊联合GP化疗治疗晚期NSCLC的效果确切,可有效减轻机体免疫抑制,改善相关肿瘤标志物水平,同时可减少不良反应发生,临床应用价值较高。

Objective To investigate the efficacy of Compound Cantharidin Capsules combined with Gemcitabine and Cisplatin(GP)chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC).Methods Eighty-two patients with advanced NSCLC admitted to Part Two in the First Hospital of Jilin University from January 2017 to December 2019 were selected,they were divided into control group(n=41)and study group(n=41)by random number table method.Control group was treated with GP chemotherapy regimen.Study group was treated with Compound Cantharidin Capsules on this basis.Clinical efficacy,immune function and tumor markers related indicators of two groups were compared,and the occurrence of adverse reactions of two groups was recorded.Results Total effective rate of study group was higher than that of control group(P<0.05).After treatment,the levels of CD3+,CD4+,CD4+/CD8+and NK cells in two groups were lower than those before treatment,and the level of CD8+was higher than that before treatment,but the levels of CD3+,CD4+,CD4+/CD8+and nature killer(NK)cells in study group were higher than those in control group,and the level of CD8+was lower than that in control group(P<0.05).After treatment,the levels of carcinoembryonic antigen,squamous cell carcinoma associated antigen and cytokeratin 19 fragment in two groups were lower than those before treatment,and those in study group were lower than those in control group(P<0.05).The incidence rate of adverse reactions in study group was lower than that in control group(P<0.05).Conclusion Compound Cantharidin Capsules combined with GP chemotherapy is effective in the treatment of advanced NSCLC.It can effectively alleviate immune suppression,improve the level of relevant tumor markers,and reduce the incidence of adverse reactions.It has high clinical value.