摘要
Sestrins是高度保守的应激诱导蛋白,可帮助维持代谢稳态并在应激条件下保护细胞。Sestrin2抑制氧化应激并调节AMP依赖的蛋白激酶-雷帕霉素靶点复合物(the AMP activated protein kinase-mammalian target of rapamycin complex,AMPK-mTORC)信号通路,在机体发生肿瘤、衰老退行性疾病、代谢性疾病、免疫性疾病时发挥保护作用。
Sestrins are highly conserved stress-inducible proteins that help maintain metabolic homeostasis and protect cells under stress conditions.The role of Sestrin2 inhibits oxidative stress and regulates the AMP activated protein kinase-mammalian target of rapamycin complex(AMPK-mTORC)signaling pathway,which protects the body from tumors,aging and degenerative diseases,metabolic diseases,and immune diseases.
作者
杨永(综述)
杨树森(审校)
YANG Yong;YANG Shusen(Department of Cardiology,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《临床与病理杂志》
CAS
2021年第2期410-414,共5页
Journal of Clinical and Pathological Research
基金
哈尔滨市科技创新人才研究专项基金(2016RAXYJ061)。
