DNA构象多态性对肿瘤生物学行为影响的研究进展

Research progress in the effects of DNA conformation polymorphism on tumor biological behavior

获得性DNA损伤可导致体细胞基因突变或失活,与肿瘤的发生发展有关。传统的研究主要针对B-DNA双链结构中Watson-Crick碱基互补对的改变对DNA生物学的影响。而对DNA构象多态性(特殊DNA序列分子间或分子内氢键、不成对碱基配对等形成的多种非B-DNA三维立体空间结构)的研究尚少。对非B-DNA结构的生物学功能、转录、翻译、基因损伤及其与疾病发生发展关系的深入了解,可以提高人们对DNA三维立体空间结构对肿瘤生物学行为影响方面的认识。

Acquired DNA damage can lead to mutation or inactivation of somatic genes,which is related to the occurrence and development of tumors.Traditional research focused on the effects of changes in Watson-Crick complementary base pairs in B-DNA double-stranded structures on DNA biology.However,there are few studies focusing on the various three-dimensional spatial structures of non-B-DNA formed by intermolecular or intramolecular hydrogen bonding or unpaired base pairing of specific DNA sequences,that is,DNA conformation polymorphism.An in-depth knowledge of the biological functions,transcription,translation,gene damage of non B-DNA structures and its association between the occurrence and development of disease can improve the understanding of three-dimensional DNA structure’s impact on.