急性胆管炎中血清标志物的研究现状

Research status of serum markers in acute cholangitis

急性胆管炎是一种威胁生命的胆道细菌感染,能否及早诊断、评估疾病严重程度直接关系到患者的治疗效果与预后。长期以来对血清中标志物的研究较多,如降钙素原(procalcitonin,PCT)、血清糖类抗原CA19-9(carbohydrate antigen 19-9)、血清前白蛋白(prealbumin,PA)、高迁移率蛋白-1(high mobility group box 1,HMGB1),这些标志物与急性胆管炎病理生理均有密切联系。

Aute cholangitis is a life-threatening bacterial infection of the bile duct and the early diagnosis and evaluation of the severity of cholangitis patients are therefore directly related to the treatment response and prognosis.For a long time,there are numbers of studies on serum markers,such as procalcitonin(PCT),serum carbohydrate antigen 19-9(CA19-9),prealbumin(PA)and high mobility group box 1(HMGB1).These markers are closely associated to the pathophysiology of acute cholangitis.This review summarizes the research status of the above markers.