多囊肾囊内感染与肾移植

Intracapsular infection of polycystic kidney disease and renal transplantation

常染色体显性多囊肾病(ADPKD)是一种常见的单基因遗传性肾病,可进展为终末期肾病(ESRD)。ADPKD患者常反复发生囊内感染,抗生素治疗所产生的耐药性问题日益突出,肾移植手术方式也需根据多囊肾的感染情况进行选择。本文从肾囊肿起源、囊肿的分类及囊液的来源、囊液内细菌类型及其耐药性、ADPKD患者囊内感染与肾移植治疗等方面进行综述,为ADPKD患者囊内感染的诊治提供参考。

Autosomal dominant polycystic kidney disease(ADPKD)is a common monogenic hereditary kidney disease,which can progress into end-stage renal disease(ESRD).Patients with ADPKD constantly suffer from recurrent intracapsular infection.The drug resistance caused by antibiotic treatment is becoming increasingly prominent.The pattern of renal transplantation should be selected according to the infection of polycystic kidney disease.In this article,the origin of renal cyst,classification and source of cystic fluid,type and drug resistance of bacteria in the cystic fluid,and intracapsular infection of patients with renal transplantation-associated ADPKD were reviewed,aiming to provide reference for the diagnosis and treatment of intracapsular infection of patients with ADPKD.