介孔二氧化硅纳米颗粒及其承载药物在心肌保护中的应用

Mesoporous silica nanoparticles and application of their drug-loading ability in myocardial protection

纳米生物材料在医学成像、药物输送、临床诊断和治疗等领域受到越来越多的关注。介孔二氧化硅纳米颗粒(Mesoporous silica nanoparticles,MSN)因其独特的优势在药物递送和生物医学中得到广泛应用,但其安全性和应用效果需要进一步的深入研究。本文对MSN的生物相容性、载药释放及其承载药物在心肌保护中的应用作一综述。

Nano-biomaterials have attracted more and more attention in the fields of medical imaging,drug delivery,clinical diagnosis and treatment.Mesoporous silica nanoparticles(MSN)have been widely used in drug delivery and biomedicine due to their unique advantages,but their safety and application effects need further study.Here,the biocompatibility and drug releasing characters of MSN as well as the application of their loaded drugs in myocardial protection were reviewed.