The Expression and Clinical Significance of Sema4A in Triple Negative Breast Cancer
摘要
Objective:To explore the expression and clinical significance of Sema4A in triple-negative breast cancer.Metlods:Eighty patients with invasive ductal carcinoma of the breast and 40 normal tissues adjacent to cancer were selected.Immumohistochemical methods were used to detect the expression of Sema4A in breast cancer and normal tissues adjacent to cancer,and its relationship with breast cancer clinicopathological features and prognosis.Results:The expression of Sema4a in the serum of BCA patients was significantly higher than that of healthy controls.In addition,the expression of sema4a in BCA cells and in the cell supernatants was also up-regulated under hypoxia.Conclusion:Exogenous Sema4A can protect BCA cells from hypoxia-induced cytotoxicity,inhibit cell apoptosis and promote cell proliferation.
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共引文献3
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1柯萍,邬万新,袁琳娜,温晓伟,陆宁.胃癌中HER-2/neu蛋白表达与临床病理特点的关系[J].中国医师杂志,2014,16(3):373-374.
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3李玉珠,李亚平,李彦良.HER-2蛋白表达与多层螺旋CT胃癌征象相关性分析及应用[J].影像科学与光化学,2021,39(5):684-688. 被引量：6
