摘要
新型冠状病毒全球大流行,危重症新型冠状病毒肺炎患者合并细胞因子风暴成为临床亟待解决的难题。低剂量放疗曾短暂用于肺炎的治疗。过去数十年,研究者一直致力于阐明低剂量放疗的生物学机制。低剂量放疗具有炎症抑制作用,已在危重症新型冠状病毒肺炎中取得了初步的效果,受到了学术界和放疗界的重点关注。本文回顾了低剂量放疗在肺炎中的应用,阐述了其放射生物学机制,介绍了低剂量全肺放疗在危重症新型冠状病毒肺炎中的初步研究结果,分析了其面临的问题,展望了其临床应用前景。
With the global pandemic of COVID-19,cytokine storms in critical patients with pneumonia is really a problem and need to be solved immediately.Low dose radiation therapy(LDRT)has been temporarily used to treat pneumonia.In the past decades,researchers were dedicated to clarify the biological mechanism of LDRT.LDRT plays a unique role in the suppression of inflammation,preliminary outcomes have been acquired in critical patients with COVID-19 pneumonia,and radiotherapy community is paying attention to this treatment strategy.This review summarizes the application of LDRT in pneumonia,its biological mechanism,the result of LDRT in COVID-19 pneumonia,the existing problems and prospective in clinic.
作者
罗辉
葛红
聂文娜
刘慧
胡亚美
许文娟
邓国栋
Luo Hui;Ge Hong;Nie Wenna;Liu Hui;Hu Yamei;Xu Wenjuan;Deng Guodong(Department of Radiation Oncology,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450008,China;China-US(Henan)Hormel Cancer Institute,Zhengzhou 450003,China;Department of Respiratory and Critical Care Medicine,Zhongnan Hospital Wuhan University,Wuhan 430071,China;Department of Etiology and Carcinogenesis,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100021,China)
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2021年第2期151-154,共4页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金(81773230)。
关键词
低剂量放疗
新型冠状病毒肺炎
抗炎作用
Low dose radiation therapy
COVID-19 pneumonia
Anti-inflammatory effect
