磷酸奥司他韦致消化道出血不良反应文献分析

Literature analysis of adverse reactions of gastrointestinal bleeding induced by oseltamivir phosphate

目的:分析磷酸奥司他韦致消化道出血不良反应的发生情况及特点,为临床合理用药提供参考。方法:采用回顾性研究的方法,检索PubMed、Web of Science、Springer Link、Embase、CNKI、万方、维普等数据库中关于磷酸奥司他韦致消化道出血不良反应的个案报道文献,检索时间为各数据库自建库至2020年2月,并对相关数据进行统计分析,结果:共筛选出奥司他韦致消化道出血不良反应个案报道9例,年龄分布6~61岁,平均年龄(27.00±16.64)岁;不良反应发生时间最短为服药后4 h,最长为4 d;3例通过停药得到缓解;4例通过停药、静脉补液等对症治疗得到缓解;1例穿孔性消化溃疡患者,行穿孔修补术后好转;1例消化道出血合并药物性肝损伤,通过停药、服用肝保护剂12 d康复。结论:磷酸奥司他韦致消化道出血不良反应的报道较少,建议临床在用药期间应加强监测,避免不良反应的发生。

Objective:To explore the characteristics of gastrointestinal bleeding caused by oseltamivir phosphate,so as to provide references for rational drug use in clinic.Methods:A retrospective study was conducted to search PubMed,Web of Science,Springer Link,Embase,CNKI,Wanfang,VIP and other databases for case reports of gastrointestinal bleeding caused by oseltamivir.The retrieval time was from the establishment of each database to February 2020,and the relevant data were statistically analyzed.Results:A total of 9 cases were enrolled in this study.The age distribution was 6 years old to 61 years old with an average age of(27.00±16.64)years old.After taking drugs,the shortest and the longest occurrence time of adverse reaction was 4 hours and 4 days respectively.3 patients were relieved by drug withdrawal;4 patients were relieved by symptomatic treatment such as drug withdrawal and intravenous fluid infusion;1 patient with perforated peptic ulcer was improved after perforation repair,and 1 patient combined with drug-induced liver injury was recovered after 12 days by drug withdrawal and taking liver protector.Conclusion:There are few reports of gastrointestinal bleeding induced by oseltamivir phosphate.It should be closely monitored during the course of treatment with oseltamivir phosphate in order to avoid the occurrence of adverse drug reactions.