不同剂量阿托西班对双胎妊娠保胎的疗效分析

Analysis of the Eefficacy of Ddifferent Aatosiban Rregimens in the Ttreatment of Twin Pregnancy

目的:探讨不同剂量阿托西班对双胎妊娠保胎的疗效及安全性。方法:回顾性分析420例晚期流产的双胎妊娠孕妇的临床资料,按照宫缩抑制剂使用情况分为短疗程组、长疗程组,每组各210例,比较2组采用不同剂量阿托西班对孕妇宫缩抑制的效果、妊娠结局,并比较2组不良反应。结果:2组比较,长疗程组患者48 h未分娩率(94.28%vs 81.43%)及7 d未分娩率(78.57%vs 66.67%)高于短疗程组,差异有统计学意义(P<0.05);长疗程组患者抑制宫缩48 h有效率(99.05%vs 88.57%)、7 d有效率(87.14%vs 76.19%)高于短疗程组,差异有统计学意义(P<0.05);长疗程组孕妇足月分娩数、晚期流产或早产数、新生儿存活情况明显优于短疗程组,差异有统计学意义(P<0.05);2组不良反应如恶心、呕吐、皮肤瘙痒等比较差异均无统计学意义(P>0.05)。结论:长疗程阿托西班能够有效延长双胎孕妇妊娠时间,抑制宫缩,改善妊娠结局,且安全性较好。

Objective:To investigate the efficacy and safety of different atosiban regimens in the treatment of twin pregnancy.Methods:The clinical data of 420 pregnant women with twin pregnancy of late abortion were retrospectively analyzed.According to the use of uterine contraction inhibitors,they were divided into a short course of treatment group and a long course of treatment group,with 210 cases in each group.The effects of different doses of atosiban on the uterine contractions,pregnancy outcome and adverse reactions were compared between the two groups.Results:The 48-hour effective rate(94.28%)and the 7-day effective rate(78.57%)in the long course group were significantly higher than those in the short course group(48-hour undelivered rate:81.43%;7 d no delivery rate:66.67%),and the difference was statistically significant(P<0.05).The effective rate of inhibiting contractions in the long course group was significantly better than that of the short course group and the difference was statistically significant(P<0.05).The number of full-term deliveries(142 cases),late abortion or premature delivery(68 cases)and neonatal survival(413 cases)in the long-course group were significantly better than those in the short-course group.and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions such as nausea,vomiting and skin pruritus between the two groups(P>0.05).Conclusion:A long course of atosiban can effectively prolong the gestation time of twin pregnant women,inhibit the contractions of pregnant women,improve the pregnancy outcome and is safer.