新癀片联合盐酸米诺环素软膏治疗牙周炎效果评价

Effect of Xinhuang Tablets and Minocycline Hydrochloride Ointment on Periodontitis

目的:探讨新癀片联合盐酸米诺环素软膏治疗牙周炎的临床疗效及对炎症因子水平的影响。方法:选择牙周炎患者150例为研究对象,根据入院时间不同将其分为对照组(75例)与观察组(75例),对照组采用盐酸米诺环素软膏治疗,观察组联合新癀片治疗,疗程均为4周;观察2组临床疗效、治疗前后龈沟液炎症因子水平、不良反应情况。结果:观察组治疗总有效率(94.66%)高于对照组(82.67%),治疗后TNF-α[(3.52±0.40)vs(4.76±0.76)ng·mL^(-1)]、IL-6[(1.43±0.27)vs(1.96±0.35)pg·mL^(-1)]、CRP[(13.42±2.58)vs(17.65±3.16)mg·mL^(-1)]低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率(6.66%)高于对照组(5.34%),但差异无统计学意义(P>0.05)。结论:新癀片联合盐酸米诺环素软膏治疗牙周炎可降低患者炎症因子水平,提高临床疗效,安全性高。

Objective:To investigate the clinical effect of xinhuang tablets combined with minocycline hydrochloride ointment in the treatment of periodontitis and its effect on the level of inflammatory factors.Methods:A total of 150 patients with periodontitis admitted were selected as the research objects.Accorded to different time of admission,the patients were divided into control group(75 cases)and observation group(75 cases).The control group was treated with minocycline hydrochloride ointment,and the observation group was treated with Xinhuang tablets.The course of treatment was 4 weeks.The clinical treatment effect,inflammatory factor levels and adverse reactions of gingival crevicular fluid before and after treatment were observed and compared.Results:The total effective rate of the observation group(94.66%)vs(82.67%)was higher than the control group.After treatment,the levels of TNF-α,IL-6,CRP were lower than that of the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the observation group(6.66%)vs(5.34%)was higher than the control group,but the difference was not statistically significant(P>0.05).Conclusion:The combination of Xinhuang tablets and minocycline hydrochloride ointment in the treatment of periodontitis can significantly reduce the level of inflammatory factors in patients,improve the clinical treatment effect and have high safety.