ADAMTS5基因在口腔鳞状细胞癌中的表达及其临床意义

Expression of ADAMTS5 in oral squamous cell carcinoma and its clinical significance

目的探讨ADAMTS5在口腔鳞状细胞癌发生发展及临床中的意义。方法采用免疫组化法检测在50例口腔鳞状细胞癌及癌旁正常组织中ADAMTS5蛋白表达情况,并分析ADAMTS5表达与患者临床病理特征的关系。结果在口腔鳞状细胞癌组织中,ADAMTS5的阳性表达率为64%,癌旁组织为30%,两组差异有统计学意义(P<0.01)。ADAMTS5在小于50岁患者中的表达高于50岁以上的患者;在低分化中的表达高于高中分化者;在有淋巴结转移者中的表达高于无淋巴结转移者,上述差异均有统计学意义(P<0.05);ADAMTS5表达与性别、发病部位、肿瘤大小等无关,差异均无统计学意义(P>0.05)。结论ADAMTS5在口腔鳞状细胞癌中高表达,并且与口腔鳞状细胞癌患者的病理分化程度、是否有淋巴结转移等相关,是潜在的口腔鳞状细胞癌预后不良因子和治疗靶点。

Objective To investigate the expression and its clinical significance of a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)in oral squamous cell carcinoma.Methods The expression of ADAMTS5 was detected in 50 cases of oral squamous cell carcinoma and their adjacent normal tissues by immunohistochemical staining,and its correlation with clinicopathological features in patients with oral squamous cell carcinoma was analyzed.Results The positive expression rate of ADAMTS5 was 64% in oral squamous cell carcinoma tissues and 30% in paracancer tissues,and there was statistically significant difference between the two groups(P<0.01).ADAMTS5 expression in patients younger than 50 years was higher than that in patients older than 50 years(P<0.05).The expression of ADAMTS5 in low differentiation tissues was higher than that in high differentiation(P<0.05).The expression of ADAMTS5 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P<0.05).The expression of ADAMTS5 was not statistically correlated with gender,site of disease and tumor size(P>0.05).Conclusion ADAMTS5 is highly expressed in oral squamous cell carcinoma,and is associated with the degree of pathological differentiation and lymph node metastasis in patients with oral squamous cell carcinoma,suggesting that ADAMTS5 is a novel potential prognostic indicator and therapeutic target in oral squamous cell carcinoma.