龙血竭治疗宫颈炎疗效及安全性的Meta分析

A Meta-analysis of clinical efficacy and safety of Longxuejie on cervicitis

系统评价龙血竭治疗宫颈炎的临床疗效及安全性,为临床诊疗提供循证依据。利用计算机检索PubMed、Embase、The Cochrane Library、中国生物医学文献服务系统(Sino Med)、中国知网(CNKI)、维普数据库(VIP)、万方数据库(WANFANG)中自建库至2020年4月公开发表的中英文文献。排除重复、动物试验、个案报道、综述类文献,筛选符合纳入标准的随机对照实验(Randomized Controlled Trial,RCT),最终纳入9个RCT,共计1193例患者,其中龙血竭治疗组603例,对照组590例。提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果显示,与对照组相比,龙血竭治疗组可提高有效率和治愈率;3个研究显示龙血竭治疗组分泌物评分和宫颈病变程度评分均低于对照组,6个研究显示龙血竭治疗组免疫球蛋白(Immunoglobulin,Ig)A、IgM及IgG水平高于对照组且差异具有统计学意义(P<0.05),同时所纳入研究均未报道明显不良反应发生。目前有限的证据表明应用龙血竭治疗宫颈炎可以提高临床疗效,但由于所纳入研究质量不一,尚需更多设计严谨、多中心、大样本、随机、双盲、实验设计完善的高品质研究进一步加以验证。

The clinical effect and safety of Longxuejie(龙血竭)on cervicitis was systematically reviewed in this article,in order to provide evidence-based reference for clinical treatment.The Chinese and English related literatures published from the date of database construction to April 2020 in PubMed,EMbase,The Cochrane Library,Sino Med database,CNKI database,VIP database and WANFANG database were researched.After eliminating duplication,animal experiment,case report and review literatures,the randomised controlled trials meeting the inclusion criteria were screened,finally 9 RCTs were enrolled in the review,which involved 1193 cases including 603 cases in the treatment group and 590 cases in the control group.After extracting data and evaluating the risk of bias in the included studies,Meta analysis was conducted by RevMan 5.3 statistical software.The results of Meta-analysis showed that compared with conventional treatment,Longxuejie can enhance the total efficiency and the cured rate.3 RCTs showed that the scores of secretion and cervical lesions in the treatment group were lower than those in the control group.6 RCTs showed that the levels of IgA,IgM and IgG in the treatment group were higher than those in the control group,and the difference between the groups was significant(P<0.05).There was no significant adverse reaction in the enrolled literatures.There is currently limited evidence that the application of Longxuejie in treating cervicitis can improve the clinical efficacy.However,due to the different quality of the research included,more high-quality studies with rigorous design,multi-center,large sample,randomized,double-blind and perfect experimental design are needed to verify the result furtherly.