中药降脂汤联合辛伐他汀治疗非酒精性脂肪肝疗效观察

Clinical observation on treating non-alcoholic fatty liver disease with the Jiangzhi decoction plus simvastatin

目的:观察对非酒精性脂肪肝(Nonalcoholic Fatty Liver Disease,NAFLD)应用中药降脂汤联合辛伐他汀进行治疗的疗效。方法:从2016年8月-2019年8月期间于我院接受治疗的非酒精性脂肪肝患者中选取45例,给予其辛伐他汀进行治疗,以此作为本次研究的对照组;另取同期45例患者,在对照组的治疗基础上联合应用中药降脂汤进行治疗,以此作为本次研究的试验组。观察并对比患者的血脂水平、肝功能指标变化及中医症状积分。结果:治疗后,试验组患者的总胆固醇(Total Cholesterol,TC)、三酰甘油(Triglycerides,TG)及低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)水平较对照组患者明显下降(P<0.05);试验组患者的丙氨酸氨基转移酶(Alanine Transaminase,ALT)、门冬氨酸氨基转移酶(Aspartate Aminotransferase,AST)、碱性磷酸酶(Alkaline Phosphatase,ALP)及γ-谷氨酰转肽酶(Gamma-glutamyl Transferase,GGT)数值较对照组患者下降明显(P<0.05)。治疗前,两组患者主症、次症证候积分差异无统计学意义(P>0.05);治疗后,试验组患者主症、次症症状积分均显著低于对照组,差异有统计学意义(P<0.05)。结论:对非酒精性脂肪肝患者应用中药降脂汤联合辛伐他汀进行治疗,可以有效改善临床症状,降低血脂水平,对患者的恢复及预后具有积极作用。

Objective:To observe the curative effects of the Jiangzhi decoction(降脂汤)plus simvastatin on NAFLD.Methods:45 cases were treated in our hospital from August 2016 to August 2019 were given simvastatin and selected as the control group of this study.Another 45 cases in the experimental group were treated with simvastatin plus the Jiangzhi decoction.Results:After treatment,the levels of TC,TG and LDL-C in the experimental group were significantly lower than those in the control group(P<0.05),the value of ALT,AST,ALP and GGT in the experimental group was significantly lower than the control group(P<0.05).Before treatment,there was no significant difference in the scores of the primary and secondary syndromes between the groups(P>0.05).After treatment,those scores in the experimental group were significantly lower than those in the control group,with significant differences(P<0.05).Conclusion:Treating NAFLD with the Jiangzhi decoction with simvastatin can effectively improve the clinical symptoms,reduce the patient’s blood lipid level,and shows a positive effect on the recovery and prognosis.