溃疡性结肠炎相关肿瘤3例诊疗报道并文献复习

Ulcerative colitis associated tumor:three cases report and literature review

目的探讨溃疡性结肠炎(ulcerative colitis,UC)相关肿瘤的临床特点、诊治、预后。方法对3例UC相关肿瘤患者的临床资料进行回顾性分析并复习相关文献。结果3例UC相关肿瘤患者病程均超过10年;肠镜提示肿瘤性病变均为息肉样病变;2例为广泛结肠型结肠炎,1例为左半结肠型结肠炎;病理1例提示癌,2例活检组织提示中-度和重度异型增生;异型增生患者内镜下切除后经规范5-氨基水杨酸(5-aminosailcylic acid,5-ASA)治疗及内镜下监测,病变处于黏膜愈合;1例癌变患者因未及时治疗,后期出现肿瘤多处转移。结论UC相关肿瘤患者病程长,多见于广泛结肠受累的患者,以息肉样病变为主的肿瘤性病变可以内镜下切除,辅以规范治疗及监测,预后较好。

Objective To investigate the clinical features,diagnosis,treatment and prognosis of ulcerative colitis(UC)associated tumor.Methods Three patients of the clinical data which were suffered from UC associated tumor was analyzed.Results The course of 3 patients’disease was all above 10 years,in which 2 patients were E3,1 patient was E2.One of the pathology was cancer,who refused standard treatment and the cancer diverted at last;the other two were moderate-severe dysplasia,they received timely endoscopic excision of lesion of large intestine,standard 5-aminosailcylic acid(5-ASA)treatment and regular inspection through endoscope,the disease turned into mucosal healing period.Conclusion Most of the UC associated tumor patients have long course of disease,and most of them are E3.They could have favourable prognosis if they accept timely endoscopic excision of lesion of large intestine,standard medication and regular inspection through endoscope.