维生素D辅助低分子肝素钙对子痫前期母体血清维生素D水平及妊娠结局的影响

Effect of vitamin D assisted low molecular weight heparin calcium on maternal serum vitamin D level and pregnancy outcome in preeclampsia

目的观察维生素D辅助低分子肝素钙对子痫前期母体血清维生素D水平及妊娠结局的影响。方法选择2017年5月—2020年1月新疆医科大学第一附属医院产科诊治子痫前期患者100例作为研究对象,随机数字表法分为对照组(n=50)和观察组(n=50)。对照组患者给予低分子肝素钙治疗,观察组在上述治疗的基础上加用维生素D辅助治疗。比较2组患者母体血清学指标及妊娠结局的差异。结果与治疗前比较,2组患者治疗后TT、FIB及血清LDL-C、TG、TC、S/D值明显降低,血清维生素D、PT、APTT及血清HDL-C、羊水量明显升高,且观察组变化更明显(t/P=7.153/<0.001,6.314/<0.001,13.461/<0.001,9.988/<0.001,8.004/<0.001,10.519/<0.001,12.715/<0.001,6.022/<0.001,3.955/<0.001,5.330/<0.001,10.338/<0.001)。治疗后,观察组患者视网膜病变分级与对照组比较,差异具有统计学意义(χ^(2)/P=10.231/<0.001)。2组患者妊娠结局比较差异无统计学意义(P>0.05)。结论维生素D辅助低分子肝素钙治疗子痫前期患者,可以有效升高母体血清维生素D水平,改善机体凝血功能和脂质代谢,增加羊水量,降低脐动脉S/D值,效果显著。

Objective To observe the effect of vitamin D-assisted low-molecular-weight heparin calcium on maternal serum vitamin D levels and pregnancy outcome in preeclampsia.Methods From May 2017 to January 2020,100 patients with preeclampsia diagnosed and treated in the Obstetrics Department of the First Affiliated Hospital of Xinjiang Medical University were selected as the research objects.Random number table method was divided into control group(n=50)and observation group(n=50).Patients in the control group were treated with low-molecular-weight heparin calcium,and the observation group was treated with vitamin D on the basis of the above treatment.Compare the differences in maternal serum indexes and pregnancy outcomes between the two groups.Results Compared with before treatment,TT,FIB and serum LDL-C,TG,TC,S/D values of the two groups were significantly reduced after treatment,and serum vitamin D,PT,APTT,serum HDL-C,and amniotic fluid volume were significantly increased.Group changes were more obvious(t/P=7.153/<0.001,6.314/<0.001,13.461/<0.001,9.988/<0.001,8.004/<0.001,10.519/<0.001,12.715/<0.001,6.022/<0.001,3.955/<0.001,5.330/<0.001,10.338/<0.001).After treatment,the grading of retinopathy in the observation group was compared with the control group,and the difference was statistically significant(χ^(2)/P=10.231/<0.001).There was no significant difference in pregnancy outcomes between the two groups(P>0.05).Conclusion Vitamin D assisted low-molecular-weight heparin calcium in the treatment of patients with preeclampsia can effectively increase maternal serum vitamin D levels,improve the body's coagulation function and lipid metabolism,increase amniotic fluid volume,and reduce umbilical artery S/D values.