改良型无抽搐电休克联合重复经颅磁刺激治疗女性重度抑郁症患者的效果及对认知功能、抑郁状态的影响

Effect of modified electroconvulsive therapy combined with repetitive transcranial magnetic stimulation in the treatment of female patients with severe depression and its influence on cognitive function and depression

目的探讨改良型无抽搐电休克(MECT)与重复经颅磁刺激(rTMS)联合治疗对女性重度抑郁症患者认知功能的影响。方法选取2018年1月~2020年2月鞍山市精神卫生中心接诊的94例女性重度抑郁症患者作为研究对象,按照随机数字表法将其分为两组,每组各47例。试验组患者行MECT联合rTMS治疗,对照组患者行单一MECT治疗。比较两组患者的临床疗效、抑郁状态、认知功能。结果试验组患者的治疗总有效率为93.62%,高于对照组的74.47%,差异有统计学意义(P<0.05)。治疗后,试验组患者的汉密尔顿抑郁量表(HAMD)评分为(14.29±3.47)分,低于对照组的(17.55±3.98)分,差异有统计学意义(P<0.05)。治疗后,试验组患者的总反应数、正确应答数、完成分类数均高于对照组,错误应答数、持续错误数均低于对照组,差异有统计学意义(P<0.05)。结论MECT与rTMS联合治疗女性重度抑郁症患者可增强疗效,改善其抑郁状态、认知功能,促进病情恢复。

Objective To investigate the effect of modified electroconvulsive therapy(MECT)combined with repetitive transcranial magnetic stimulation(rTMS)on cognitive function in women patients with severe depression.Methods From January 2018 to February 2020,94 female patients with severe depression who were admitted to Anshan Mental Health Center were selected as the research subjects,and they were divided into two groups according to the random number table method,with 47 cases in each group.The experimental group underwent MECT combined with rTMS,the control group was treated with single MECT.The clinical efficacy,depression status and cognitive function of the two groups were compared.Results The total effective rate of treatment in the experimental group was 93.62%,which was higher than 74.47%in the control group,the difference was statistically significant(P<0.05).After treatment,the Hamilton depression rating scale(HAMD)score of the experimental group was(14.29±3.47)points,which was lower than that of the control group for(17.55±3.98)points,the difference was statistically significant(P<0.05).After treatment,the total number of responses,the number of correct responses and the number of completed classifications of patients in the experimental group were higher than those in the control group,and the number of wrong responses and persistent errors were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion MECT combined with rTMS can enhance the curative effect,improve the depressive state,cognitive function and promote the recovery of female patients with severe depression.