奥美拉唑联合奥曲肽治疗老年肝硬化并上消化道出血的临床效果

Clinical effect of Omeprazole combined with Octreotide in the treatment of senile cirrhosis with upper gastrointestinal bleeding

目的研究奥美拉唑联合奥曲肽治疗老年肝硬化并上消化道出血的临床效果。方法选取2018年3月~2020年3月沈阳市第四人民医院收治的80例老年肝硬化并上消化道出血患者作为研究对象,采用随机抽签分组原则将其分为观察组和对照组,每组各40例。观察组患者采用奥美拉唑联合奥曲肽治疗方式,对照组患者采用常规治疗方式。比较两组患者的住院时间、止血时间、不良反应总发生率、输血量、总有效率、呕血症状消失时间、黑便症状消失时间。结果观察组患者的住院时间、止血时间短于对照组,输血量少于对照组,差异有统计学意义(P<0.05);观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应总发生率低于对照组,差异有统计学意义(P<0.05);观察组患者的呕血症状消失时间、黑便症状消失时间短于对照组,差异有统计学意义(P<0.05)。结论通过对老年肝硬化并上消化道出血患者实施奥美拉唑、奥曲肽联合治疗,能取得较高的有效率,值得临床推广。

Objective To study the clinical effect of Omeprazole combined with Octreotide in the treatment of senile cirrhosis with upper gastrointestinal bleeding.Methods A total of 80 elderly patients with cirrhosis and upper gastrointestinal bleeding treated in the Fourth People′s Hospital of Shenyang City from March 2018 to March 2020 were selected as study subjects,and were divided into the observation group and the control group by the randomized sortition grouping principle,with 40 patients in each group.Patients in the observation group were treated with Omeprazole combined with Octreotide,while patients in the control group were treated with conventional treatment.The lengths of hospital stay,hemostatic time,total incidence of adverse events,blood transfusion volumes,total effective rate,hematemesis disappearance time and melena disappearance time were compared between the two groups.Results The length of hospital stay and hemostatic time of the observation group were shorter than those of the control group,and the blood transfusion volume was less than that of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).The total incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The hematemesis symptom disappearance time and melena symptom disappearance time in the observation group were shorter than those in the control group,with statistically significant differences(P<0.05).Conclusion The combination of Omeprazole and Octreotide in elderly patients with cirrhosis and upper gastrointestinal bleeding has achieved a high effective rate.It is worthy of clinical promotion.