不同孕期SF和GH水平变化及其与GDM的相关性研究

Changes of SF and GH levels in different gestational periods and their correlation with GDM

目的探讨妊娠期孕妇血清铁蛋白(SF)和生长激素(GH)的含量变化及其与妊娠糖尿病(GDM)的相关性。方法将GDM孕妇141例作为研究组,其中孕早期组34例,孕中期组57例,孕晚期组50例,同时匹配相应孕期健康孕妇162例为对照组,测定血清SF、GH、空腹胰岛素(FINS)及空腹血糖(FBS)水平,计算胰岛素抵抗指数(HOMA-IR)并统计分析。结果 GDM孕早期组、孕中期组、孕晚期组血清SF、FINS、HOMA-IR水平均显著高于对照组,差异有统计学意义(P<0.05),但GH水平在各孕期与对照组比较差异无统计学意义(P>0.05)。对GDM孕早期组、孕中期组、孕晚期组进行方差分析发现,血清SF、FINS、HOMA-IR水平孕期间差异有统计学意义(P<0.05)。对照组孕妇各组孕期间的SF、GH差异有统计学意义(P<0.05),FINS、HOMA-IR差异无统计学意义。相关分析显示,GDM孕妇血清中SF含量与FINS和GH呈负相关性(P<0.05),其余指标之间无相关性(P>0.05)。结论 GDM孕妇体内存在严重的胰岛素抵抗,SF和GH之间存在负相关性,与GDM的发生有关。

Objective To investigate the changes of serum ferritin(SF)and growth hormone(GH)levels in pregnant women and analyse their correlation with gestational diabetes mellitus(GDM).Methods 141 pregnant women with GDM(experimental group)and 162 healthy pregnant women(control group)were each divided into early-pregnancy(34 cases),mid-pregnancy group(57 cases)and late-pregnancy(50 cases).Serum levels of SF,GH,Insulin(FINS)and Fasting plasma glucose(FBS)were measured,insulin resistance index(HOMA-IR)was calculated and analyzed.Results The serum levels of SF,FINS and HOMA-IR in experimental group were significantly higher than those in control group(P<0.05),but there was no significant difference in GH level(P>0.05).Analysis of variance showed that there were significant differences in serum SF,FINS and HOMA-IR levels among early-pregnancy,mid-pregnancy and late-pregnancy(P<0.05).In the control group,there were significant differences in SF and GH(P<0.05),but there were no significant differences in fins and HOMA-IR.Correlation analysis showed that SF content in serum of GDM pregnant women was negatively correlated with fins and GH(P<0.05).There was no correlation between other indexes(P>0.05).Conclusion There is severer insulin resistance in pregnant women with GDM.There is a negative correlation between SF and GH,which related to the occurrence of GDM.