异构酶在生物制造中的研究进展

Recent advances on isomerases for bio-manufacturing

异构体是指具有相同分子式而原子空间排布不同的化合物,异构体现象在自然界中广泛存在,例如常见的糖类、氨基酸、手性药物等化合物。催化异构体之间相互转化的反应即为异构反应,生物体内的异构反应主要通过异构酶来实现。随着现代生物技术的不断发展,越来越多的异构酶获得了挖掘、研究、应用,多种化合物可以通过生物异构反应来制造,这对于化工产业是强有力的补充与发展。研究人员结合自身工作,综述了近年来异构酶在生物化工领域的研究与应用进展。

Isomers are chemical compounds that have the same molecular formula but different space arrangements of atoms.Isomers are widely existed in nature,including lots of sugar,amino acids,and chiral drugs.The transformation between different isomers is called isomerization.The isomerization reaction in vivo was mainly catalyzed by isomerases.With the development of modern biotechnology,more and more isomerases have been investigated and used for different applications.Lots of chemicals can be produced through catalysis of isomerases,showing a powerful supplementary to the chemical industry.Based on our research,recent studies of isomerization reactions in biochemical field were reviewed.