线粒体功能受损与多囊卵巢综合征发生胰岛素抵抗相关性的研究进展

Research progress on the relationship between mitochondrial dysfunction and insulin resistance in polycystic ovary syndrome

多囊卵巢综合征(PCOS)是妇科临床常见疑难病,治愈率较低,具有遗传性。其内分泌紊乱的疾病特点严重影响女性的一生,且发病机制复杂多样。胰岛素抵抗(IR)是伴随本病常见的内分泌表现,与PCOS远期并发症和不良妊娠结局关系密切,并可加重本病另一内分泌特征——高雄激素血症。近年来,线粒体功障碍与本病相关的发病机制备受关注,研究发现,其对PCOS-IR也存在着多方面的直接的影响。线粒体DNA受损、线粒体转运RNA基因突变、氧化应激等都影响着线粒体正常功能的行使,而导致或加剧PCOS-IR。本文主要就线粒体功能受损与PCOS-IR间的相互影响进行综述。

Polycystic ovary syndrome(PCOS)is a common and difficult disease in clinical gynecology,with low cure rate and hereditary.The characteristics of endocrine disorders seriously affects women’s life,and its pathogenesis is complex and diverse.Insulin resistance(IR)is a common endocrine manifestation associated with PCOS,which is closely related to long-term complications of PCOS and adverse pregnancy outcomes,and may aggravate another endocrine characteristic of this disease--hyperandrogenemia.In recent years,the pathogenesis of mitochondrial dysfunction and this disease has attracted much attention.It has been found that it also has direct effects on PCOS-IR in many aspects.Mitochondrial DNA damage,mitochondrial transport RNA gene mutation,oxidative stress and so on affect the normal function of mitochondria,leading to or aggravating PCOS-IR.In this paper,the interaction effect between impaired mitochondrial function and PCOS-IR is reviewed.