磷酸西格列汀联合二甲双胍对2型糖尿病患者血糖控制及胰岛素抵抗的治疗效果

Therapeutic effect of Sitagliptin Phosphate combined with Metformin on blood glucose control and insulin resistance in patients with type 2 diabetes mellitus

目的探讨磷酸西格列汀联合二甲双胍对2型糖尿病患者血糖控制及胰岛素抵抗改善的影响,为患者诊疗提供依据。方法选取2019年4月—2020年4月安徽省阜阳市妇女儿童医院收治的2型糖尿病患者80例作为研究对象,采用随机数字表法将其分观察组和对照组,每组40例。对照组采用二甲双胍治疗,观察组采用磷酸西格列汀联合二甲双胍治疗。两组均治疗12周。比较两组治疗后的效果,记录两组治疗前后空腹血糖(FBG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)变化,统计两组治疗期间不良反应。结果观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组的FBG、2hPBG、HbA1c均低于对照组,差异均有统计学意义(均P<0.05);观察组的FINS高于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论磷酸西格列汀联合二甲双胍治疗2型糖尿病效果确切,可有效改善血糖,提高患者胰岛β细胞分泌功能,降低胰岛素抵抗,具有较高的安全性。

Objective To investigate the effect of Sitagliptin Phosphate combined with Metformin on the improvement of blood glucose control and insulin resistance in patients with type 2 diabetes mellitus,and to provide evidence for the diagnosis and treatment of patients.Methods Eighty patients with type 2 diabetes mellitus who were admitted to Fuyang Women’s and Children’s Hospital,Anhui Province from April 2019 to April 2020 were selected as the research subjects.They were divided into observation group and control group by random number table method,with 40 cases in each group.The control group was treated with Metformin and the observation group was treated with Sitagliptin Phosphate combined with Metformin.Both groups were treated for 12 weeks.The effects of treatment were compared between the two groups.The changes of fasting blood glucose(FBG),2 h postprandial blood glucose(2hPBG),glycosylated hemoglobin(HbA1c)and fasting insulin(FINS)before and after treatment were recorded in the two groups,and the adverse reactions during treatment in the two groups were counted.Results The total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant(P<0.05).After treatment,FBG,2hPBG and HbA1c in the observation group were lower than those in the control group,with statistical significance(all P<0.05).FINS in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sitagliptin Phosphate combined with Metformin has a definite effect on the treatment of type 2 diabetes mellitus,which can effectively improve blood glucose,improve the secretion function of pancreatic β cells,reduce insulin resistance,and has a high safety.