细菌对抗菌化合物的交叉与共耐药研究

Cross-and co-resistance to antibacterial compounds

目前细菌对抗菌药物的耐药形势日渐严峻。广泛应用于医疗、农业和食品等方面的非系统药用抗菌化合物(消毒剂、防腐剂和杀虫剂等),在提供消毒保健的同时却可促使细菌产生对各类抗菌化合物的交叉或共耐药。为此,本文重点综述了细菌对抗菌药物与消毒剂、抗菌肽和重金属类化合物的交叉及共耐药,并探讨了活性氧簇(ROS)与细菌交叉或共耐药间潜在的联系,以期增进我们对细菌如何产生对抗菌药物与非药物抗菌化合物的广泛、交叉及共耐药的理解,为制定更好的抗感染治疗策略提供参考。

The trend of bacterial resistance to antibacterial drugs is becoming more and more serious. Nondrug antibacterial compounds(e.g., disinfectants, preservatives, and insecticides) used in health care, agricultural, food, and other fields not only can help achieve disinfection, preservation, and hygiene, but they can also promote the development of cross-resistance and/or co-resistance to various antibacterial compounds. In the present review, we focus on the bacterial cross-resistance and co-resistance to antibacterial drugs, disinfectants, antimicrobial peptides, and heavy metal compounds, as well as on the potential connection of reactive oxygen species(ROS) with bacterial cross-resistance or co-resistance. Such information will help better understand bacterial resistance to diverse antibacterial compounds and develop new anti-infective treatment strategies.