头孢卡品内酯化合物盐酸盐的合成及结构确证

The synthesis and structural confirmation of cefcapene lactone compound hydrochloride

首先将D-7-ACA与BTPA作为起始原料,进行缩合反应及内酯化反应得到中间体1;然后中间体1再经过脱保护反应得到头孢卡品内酯化合物,最后与盐酸成盐反应得到产物头孢卡品内酯化合物盐酸盐。该工艺得到的头孢卡品内酯化合物盐酸盐收率及纯度较高,原料易得。通过结构确证(紫外吸收光谱、红外吸收光谱、质谱以及核磁共振波普数据)证实了头孢卡品内酯化合物盐酸盐化学结构的正确性。

First, D-7-ACA and BTPA were used as starting materials. Then the starting materials were subjected to condensation reaction and lactonization reaction to obtain intermediate 1. Subsequently, intermediate 1 was subjected to deprotection reaction to synthesize cefcapene lactone compound. Finally, the cefcapene lactone compound was combined with hydrochloric acid to synthesize cefcapene lactone compound hydrochloride. Cefcapene lactone compound hydrochloride in high purity and yield was prepared via the process. Furthermore, the raw materials of this process were easy to obtain. The correctness of the chemical structure of cefcapene lactone compound hydrochloride was confirmed by structural confirmation(UV, IR, MS and NMR data).