用于小动物活体的荧光-光热双模成像系统

Development of Small Animals in vivo Fluorescence-photothermal Dual Mode Imaging System

报道了一种小动物活体荧光-光热双模成像系统,其兼具荧光成像和热成像双功能,具有成像灵敏度高、采集速度快(≤51 frame/s)、组织穿透深度大(近红外荧光成像时可达10 mm)以及0.1℃的热成像分辨率.该系统不但能够实现小动物皮下肿瘤和深层组织/器官的荧光成像,同时集成了热成像,可实时监测光热治疗中的温度变化以及药物的控制释放过程,有助于实现精准治疗.

This study reports a small animal in vivo fluorescence-photothermal dual-mode imaging system,which has dual functions of fluorescence imaging and thermal imaging.The system has high imaging sensitivity,fast acquisition speed(≤51 frame/s),and large tissue penetration depth(near infrared fluorescence up to 10 mm during imaging),and a thermal imaging resolution of 0.1℃.The system can not only achieve fluores⁃cence imaging of small animal subcutaneous tumors and deep tissues/organs,but also integrates thermal imaging to monitor temperature changes in photothermal therapy in real time,as well as the controlled release process of drugs to achieve precise treatment.