麝香保心丸联合尼可地尔对心肌梗死后冠状动脉微循环障碍患者心脏功能和血清学指标的影响

Effects of Shexiang Baoxian Pills Combined with Nicordil on Cardiac Function and Serological Indexes in Patients with Coronary Microcirculation Disorder after Myocardial Infarction

目的探讨麝香保心丸联合尼可地尔对心肌梗死后冠状动脉微循环障碍患者心脏功能和血清学指标的影响。方法选取沈阳市第九人民医院2017年1月至2019年10月收治的91例心肌梗死后冠状动脉微循环障碍患者作为研究对象,按照治疗方案不同分为观察组与对照组,两组给予常规对症治疗。对照组给予尼可地尔口服治疗,观察组在对照组治疗基础上联合麝香保心丸口服治疗。比较两组患者心功能指标、血清学指标。结果治疗前,两组患者心功能指标比较,差异无统计学意义(P>0.05);治疗后,两组患者心率、NYHA心功能分级赋值明显下降,左心室射血分数、心输出量明显升高,观察组患者改善幅度优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者血清学指标比较,差异无统计学意义(P>0.05);治疗后,两组患者白细胞介素-1、白细胞介素-6、超敏C反应蛋白、内皮素-1、Lp-PLA2明显下降,一氧化氮明显升高,除Lp-PLA2外,观察组其他指标改善幅度优于对照组,差异有统计学意义(P<0.05)。结论对心肌梗死后冠状动脉微循环障碍患者使用麝香保心丸联合尼可地尔联合治疗,能有效改善患者的心脏功能和血清学指标,疗效确切。

Objective To explore the effect of Shexiang Baoxin Pills combined with Nicodil on cardiac function and serological index in patients with coronary microcirculation disorder after myocardial infarction.Methods A total of 91 patients with coronary microcirculation disorder after myocardial infarction admitted to Shenyang Ninth People’s Hospital from January 2017 to October 2019 were selected as the research objects and were divided into an observation group and a control group according to different treatment regimens.Both groups were given routine symptomatic treatment.The control group was treated with nicordil orally,and the observation group was treated with nicordil plus Shexiang Baoxin Pill.Cardiac function indicators and serological indicators were compared between the 2 groups.Results Before treatment,there was no statistically significant difference in cardiac function between the 2 groups(P>0.05).After treatment,the heart rate and NYHA cardiac function grading assignment of the 2 groups of patients decreased significantly,and the left ventricular ejection fraction and cardiac output increased significantly.The degree of improvement in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in serological indicators between the 2 groups before treatment(P>0.05).After treatment,the levels of interleukin-1,interleukin-6,hypersensitive C-reactive protein,endothelin-1,Lp-PLA2,significantly decreased and nitric oxide were significantly increased in both groups.Except for LP-PLA2,the improvement degree of other indexes in the observation group was significantly higher than that in the control group,there were statistical significance(P<0.05).Conclusion For patients with coronary microcirculation disorder after myocardial infarction,the combination therapy of Shexiang Baoxin pill and Nicordil can effectively improve the cardiac function and serological indexes of patients,with definite curative effect.