多潘立酮联合酪酸梭菌活菌散对功能性消化不良患儿胃动力学的影响

Effect of Domperidone Combined with Clostridium Butyricum Powder on Gastric Dynamics in Child Patients with Functional Dyspepsia

目的探讨功能性消化不良患儿应用多潘立酮联合酪酸梭菌活菌散治疗对胃动力学的影响。方法选取营口市妇产儿童医院2018年11月至2019年11月收治的功能性消化不良患儿98例作为研究对象,采用随机数字表法分为对照组与观察组,每组49例。对照组患儿口服多潘立酮治疗,观察组患儿口服多潘立酮和酪酸梭菌活菌散治疗。连续治疗1周,比较两组临床疗效、胃动力学以及不良反应。结果与对照组治疗有效率(79.59%)比较,观察组(95.92%)较高,与对照组胃排空时间(34.78±8.30)min比较,观察组治疗后的(28.96±6.06)min较短,与对照组胃窦收缩(2.79±0.68)次/min、胃窦收缩幅度(402.63±84.36)mm^(2)比较,观察组治疗后的(3.55±0.52)次/min、(441.79±84.62)mm^(2)较高,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论功能性消化不良患儿应用多潘立酮联合酪酸梭菌活菌散治疗效果较佳,能改善胃动力学,且无严重不良反应,安全有效,利于患儿预后。

Objective To explore the effect of domperidone combined with clostridium butyricum powder on gastric motility in child patients with functional dyspepsia.Methods A total of 98 cases of functional dyspepsia admitted to Yingkou Maternity and Children’s Hospital from November 2018 to November 2019 were selected as the research objects and were randomly divided into a control group and an observation group according to random number table,with 49 cases in each group.The control group was treated with domperidone,while the observation group was treated with domperidone combined with clostridium butyricum powder.After 1 week of continuous treatment,the clinical efficacy,gastric motility and adverse reactions were compared between the 2 groups.Results Compared with the total effective rate of the control group(79.59%),the observation group(95.92%)was higher.Compared with the control group,the gastric emptying time in the observation group after treatment was(28.96±6.06)min shorter than that in the control group(34.78±8.30)min.Compared with the control group,the number of antral contraction(2.79±0.68)times/min and the amplitude of antral contraction(402.63±84.36)mm^(2)in the control group,the observation group after treatment was(3.55±0.52)times/min,(441.79±84.62)mm^(2),and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Domperidone combined with clostridium butyricum powder in the treatment of child patients with functional dyspepsia has better therapeutic effect,which can improve gastric dynamics,and has no serious adverse reactions.It is safe and effective,and is conducive to the prognosis of child patients.