抗SSA+/SSB+和抗SSA+/SSB-原发性干燥综合征患者临床及实验室特征分析

Clinical and laboratory characteristics of anti-SSA+/SSB+and anti-SSA+/SSB-primary Sjogren's syndrome

目的比较抗SSA+/SSB+和抗SSA+/SSB-pSS患者临床及实验室特征,探讨抗SSB抗体在pSS患者中的价值。方法选取2017年7月-2019年7月本院就诊的269例pSS患者为研究对象,分析抗SSA/SSB表达情况。将抗SSA+/SSB+作为观察组,抗SSA+/SSB-为对照组,比较其临床及实验室特点。结果纳入的269例pSS患者中,抗SSA+/SSB+112例(占41.6%);抗SSA+/SSB-有114例(占42.4%)。观察组和对照组间,年龄、性别、临床表现和系统性并发症的发生率差异均无统计学意义(P>0.05)观察组RF的阳性率高于对照组(P=0.008),其余免疫学指标(IgG、C3、C4和ANA)、血常规指标(WBC、NEUT、LY、HB和PLT)以及生化指标(ALT、AST、TBIL、DBIL和AFP)的变化差异均无统计学意义(P>0.05)结论抗SSA+/SSB+的pSS患者更倾向于RF阳性,除此之外,抗SSA+pSS患者是否合并抗SSB+对其临床表现和实验室特征均无影响。

Objective To compare the clinical and laboratory characteristics of anti-SSA +/SSB + and anti-SSA +/SSB-primary Sjogren’s syndrome( p SS),and explore the value of anti-SSB antibody for p SS patients. Methods A total of 269 p SS patients admitted to our hospital from July 2017 to July 2019 were selected as research objects to analyze the expression of anti-SSA/SSB. Anti-SSA +/SSB + was taken as the observation group and anti-SSA +/SSB-as the control group to compare their clinical and laboratory characteristics. Results Among the 269 p SS patients included,112 cases( 41. 6%) were anti-SSA +/SSB +,114 cases( 42. 4%) were anti-SSA +/SSB-. There was no statistical significance on the differences in age,gender,clinical manifestations and incidence of systemic complications between observation group and control group( P >0. 05). The positive rate of RF in the observation group was higher than that in the control group( P = 0. 008). There was no statistical significance on the differences in other immunological indicators( Ig G,C3,C4 and ANA),blood routine indicators( WBC,NEUT,LY,HB and PLT),and biochemical indicators( ALT,AST,TBIL,DBIL and AFP). Conclusion p SS patients with anti-SSA +/SSB + were more prone to RF positive. But,beyond that,anti-SSB + had no effect on anti-SSA + p SS patients’ clinical manifestations and laboratory characteristics.