Meta分析帕金森病患者与肠道乳酸杆菌量的关系

Relationship between patients with Parkinson’s disease and intestinal lactobacillus:a Meta-analysis

目的探讨帕金森病(PD)患者与肠道乳酸杆菌量的关系。方法本文在线检索PubMed、Embase、Cochrane、Clinicalkey、中国知网、万方数据库等数据库中关于PD患者与肠道乳酸杆菌量的病例对照研究,采用NOS量表进行评价、Revman 5.3软件进行数据分析。结果总共纳入5篇病例对照研究,共641例研究对象,其中病例组371例,对照组270例。Meta分析结果显示,PD患者肠道乳酸杆菌的量高于对照组(SMD=0.61,95%CI=0.23~0.99)。结论PD患者肠道乳酸杆菌的量高于对照组,提示该菌参与了PD的发生和发展过程。

Objective To explore the relation between patients with Parkinson’s disease(PD)and the amount of intestinal lactobacillus.Methods We retrieved online case-control studies on PD patients and amount of intestinal lactobacillus from PubMed,Embase,Cochrane,Clinicalkey,CNKI,Wanfang Database and other databases.NOS scale was used for evaluation and the software Revman 5.3 was used to analyze the data.Results A total of 5 case-control studies with 641 subjects were included,including 371 cases in the case group and 270 cases in the control group.Meta-analysis results showed that the amount of intestinal lactobacillus in PD patients was higher than that of the control group(SMD=0.61,95%CI=0.23~0.99).Conclusion The amount of intestinal lactobacillus in PD patients is higher than that of the control group,suggesting that this bacterium is involved in the occurrence and development of PD.