从阴阳调和立论探讨针刺结合豨芍方治疗疼痛的效应机制

Discussion on the effect mechanisms of acupuncture combined with Xishao Decoction in the treatment of pain from the theory of yin-yang coordination

阴阳学说是中医学的核心理论,阴平阳秘是维持人体正常生命活动的基础,阴阳失衡是疾病发生的主要原因。疼痛的核心病机包括阴阳偏盛或偏衰导致的不通则痛和不荣则痛。针刺和中药可以通过调和阴阳、疏通经脉、畅达气血,达到镇痛的目的。现代医学研究表明,环核苷酸是维持机体稳态的重要活性物质,可反映机体阴阳的基本特性。针刺结合豨芍方可通过调节异常表达的环核苷酸,恢复其正常状态,从而缓解疼痛。从阴阳立论,结合现代医学对阴阳相关物质基础环核苷酸的研究,阐明针刺结合豨芍方通过调和阴阳发挥镇痛作用的机制,为疼痛的中医药治疗提供新的理论依据。

The yin-yang theory is the core idea of traditional Chinese medicine(TCM), the coordination of yin-yang is the basis for maintaining the normal life activities of human body, and the imbalance of yin-yang is the main cause of disease. The core pathogenesis of pain include "obstruction leading to pain" and "innutrition leading to pain" caused by excess or deficiency of either yin or yang. Acupuncture and Chinese medicine can coordinate and harmonize yin-yang, dredge the channels and recover the normal circulation of qi and blood, so as to achieve the purpose of analgesia. Modern medical researches show that cyclic nucleotides are the important active substances to maintain the homeostasis of body, which can reflect the basic characteristics of yin-yang of body. Acupuncture combined with Xishao Decoction can relieve the pain by regulating the abnormal expressions of cyclic nucleotides to restore the normal state. From the theory of yin-yang, combined with the studies of cyclic nucleotides, which is the relevant material basis of yin-yang in modern medicine, this paper expounds the mechanisms of acupuncture combined with Xishao Decoction on analgesia by regulating yin-yang, in order to provide new theoretical basis for Chinese medical therapy of pain.