丹参酮Ⅱ_(A)磺酸钠联合卡维地洛对心力衰竭患者心功能及内分泌激素水平的影响

Effect of Sodium Tanshinon Ⅱ_(A) Combined with Carvedilol on Cardiac Function and Endocrine Hormone Levels in Patients with Heart Failure

目的探讨丹参酮Ⅱ_(A)磺酸钠联合卡维地洛对心力衰竭患者心功能及内分泌激素水平的影响。方法选取医院2017年8月至2019年8月收治的心力衰竭患者96例,按随机数字表法分为观察组和对照组,各48例。两组均予卡维地洛治疗,观察组加用丹参酮Ⅱ_(A)磺酸钠治疗。两组均连续治疗2周。结果观察组总有效率为89.58%,显著高于对照组的72.92%(P <0.05);治疗后,观察组患者左室射血分数(LVEF)显著高于对照组,左室收缩末期内径(LVESd)、左室舒张末期内径(LVEDd)均显著低于对照组(P <0.05),内分泌激素[血管紧张素Ⅱ(Ang-Ⅱ)、醛固酮(ALD)、血管内皮素(ET)]水平均显著低于对照组(P <0.05),炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)]水平均显著低于对照组(P <0.05);治疗期间,观察组与对照组患者不良反应发生率相当(18.75%比10.42%,P> 0.05)。结论丹参酮Ⅱ_(A)磺酸钠联合卡维地洛治疗心力衰竭临床疗效显著,能改善患者心功能,降低内分泌激素和炎性因子水平,且安全性良好。

Objective To investigate the effect of sodium tanshinonⅡ_(A)combined with carvedilol on cardiac remodeling and endocrine hormone levels in patients with heart failure.Methods Totally 96 patients with heart failure admitted to our hospital from August 2017 to August 2019 were selected and divided into the observation group and the control group according to the random number table method,48 cases in each group.The patients in the two groups were treated with carvedilol,on this basis,the patients in the observation group were treated with sodium tanshinoneⅡ_(A).Both groups were continuously treated for two weeks.Results The total effective rate of the observation group was 89.58%,which was significantly higher than 72.92%of the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the observation group was significantly higher than that in the control group,while the left ventricular end-systolic diameter(LVESd)and left ventricular end-diastolic diameter(LVEDd)in the observation group were significantly lower than those in the control group(P<0.05).The levels of endocrine hormones[angiotensinⅡ(Ang-Ⅱ),aldosterone(ALD),endothelin(ET)]in the observation group were significantly lower than those in the control group(P<0.05).The levels of inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(18.75%vs.10.42%,P>0.05).Conclusion Sodium tanshinoneⅡ_(A)combined with carvedilol is effective and safe in the treatment of patients with heart failure,which can improve cardiac function and reduce the levels of endocrine hormones and inflammatory factors.