基于中红外吸收的低成本幽门螺旋杆菌检测的光学传感系统

Low cost Helicobacter Pylori Detection Optical Sensor System Based on Mid-infrared Absorption

幽门螺旋杆菌对人体危害极大,快速的生活节奏和不健康的生活方式使其感染率极高。目前医疗方面多使用质谱仪进行幽门螺旋杆菌感染情况的检测,该仪器价格高昂、体积笨重且对操作人员的要求较高,很大程度限制了质谱仪在基层医院的推广发展。该文提出设计一款基于中红外光吸收的低成本幽门螺旋杆菌检测的光学传感系统。该系统同样利用对呼出气体中同位素标记气体进行浓度检测,通过对呼出气体中^(13)C同位素标记二氧化碳浓度的精准检测,最终完成幽门螺旋杆菌感染情况的定性分析。该光学传感系统成本低、操作简便、可行性高、检测效率高,具有更广阔的应用市场。

Helicobacter pylori is extremely harmful to the human body,and the rapid pace of life and unhealthy lifestyle make the infection rate extremely high.At present,mass spectrometers are often used in medical treatment to detect Helicobacter pylori infection.The high price,bulky size and high requirements of operators have greatly restricted the promotion and development of mass spectrometers in primary hospitals.The paper proposes to design a low cost optical sensor system for Helicobacter pylori detection based on mid-infrared light absorption.The system also uses the concentration detection of isotope-labeled gas in the exhaled gas,and through the accurate detection of the concentration of l3C isotopelabeled carbon dioxide in the exhaled gas,the qualitative analysis of Helicobacter pylori infection is finally completed.The optical sensing system has the advantages of low cost,simple operation,high feasibility,and high detection efficiency,and has a broader application market.