血塞通联合自体富血小板凝胶对糖尿病足患者血糖、AT-Ⅲ、TNF-α、24h尿蛋白等的影响分析

Effect of Xuesaitong combined with autologous platelet-rich gel on blood glucose,AT-Ⅲ,TNF-αand 24 h urine protein in patients with diabetic foot

目的探讨不同剂量血塞通联合自体富血小板凝胶对糖尿病足患者的临床疗效。方法将纳入研究的90例糖尿病足患者分为研究A组(低剂量血塞通联合自体富血小板凝胶组),研究B组(高剂量血塞通联合自体富血小板凝胶组),对照C组(仅自体富血小板凝胶组),检测3组患者相关指标变化情况。结果1)与治疗前相比,治疗后三组空腹血糖、餐后2 h血糖水平、HbA1c、TNF-α、Hcy、血尿素氮、肌酐和24 h尿蛋白水平均降低,AT-Ⅲ增加,创面肉芽组织覆盖率、肉芽组织生长厚度、创面清除率增加,溃疡面修复时间减少,以上指标变化均差异显著(P<0.05);2)与对照C组相比,研究A组、B组以上指标变化同1)且差异显著(P<0.05);3)与研究A组治疗后相比,研究B组AT-Ⅲ水平显著增加(P<0.05),TNF-α、Hcy、BUN、Cr、24 h尿蛋白水平均显著降低(P<0.05),其余指标A组、B组间无显著差异(P>0.05)。结论血塞通联合自体富血小板凝胶能有效的降低糖尿病足患者血糖水平,改善患者临床指标,促进创面愈合,且高剂量组在改善临床指标方面优势显著。

Objective To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).Methods Ninety patients with diabetic foot admitted to our hospital from February 2017 to February 2019 were enrolled in the study.According to the random number table method,the subjects were divided into study group A and B and control group C.Group A was given a low dose of Xuesaitong combined with APG,while group B was given high-dose Xuesaitong combined with APG and group C was treated only with APG.Patients in the three groups were observed and the changes of related indexes were detected.Results 1)After treatment,with regard of the three groups,the fasting blood glucose,postprandial 2 h blood glucose level,HbA1c,TNF-α,Hcy,blood urea nitrogen(BUN),creatinine(Cr)and 24 h urine protein levels were all decreased,yet AT-Ⅲlevel was increased,and granulation tissue coverage and growth thickness,wound clearance rate were increased,while the repair time of ulcer surface was significantly reduced.The above indicators were all significantly different(P<0.05).2)Compared with the control group C,the changes of the indexes in the study group A and B were the same as above,and the difference was significant(P<0.05).3)Compared with the study group A,the level of AT-Ⅲin group B was significantly increased(P<0.05),while TNF-α,Hcy,BUN,Cr and 24-hour urine protein levels were significantly decreased(P<0.05).There was no significant difference between the other indicators in group A and B(P>0.05).Conclusion Xuesaitong combined with APG can effectively reduce the blood sugar level of DF patients,improve the clinical indicators,promote wound healing,and the high-dose group has more significant advantages and is worthy of promotion.